Literature DB >> 7956167

A qualitative process theory based model of the HIV-1 virus-cell interaction.

C Ruggiero1, M Giacomini, O E Varnier, S Gaglio.   

Abstract

We present a qualitative model of the interaction between the HIV-1 virus and the human cell, based on qualitative process theory. This model takes into account a previous qualitative model of the cell growth. The model presented here can be regarded as a first step for setting up a comprehensive model of the HIV-1 virus-cell interaction in which the possible points where a drug can attack the virus are evident. The first simulation trials indicate that the presented model reproduces (even though in a simplified way) the features of the real behaviour that have been considered in the modelling phase. Although our simulation is limited in the knowledge it expresses, it still gives a stimulating opportunity for the evaluation of the criteria chosen as discriminant in the interaction between virus and cell.

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Year:  1994        PMID: 7956167     DOI: 10.1016/0169-2607(94)90077-9

Source DB:  PubMed          Journal:  Comput Methods Programs Biomed        ISSN: 0169-2607            Impact factor:   5.428


  1 in total

1.  Qualitative modelling of the response of cytoskeletal actin filaments in endothelial cells subjected to shear stress.

Authors:  C Ruggiero; M Giacomini; P Rolfe
Journal:  Med Biol Eng Comput       Date:  1999-09       Impact factor: 2.602

  1 in total

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