Literature DB >> 7955539

Transforming growth factor-beta 1 (TGF-beta 1)- and beta 2-like activities in malignant pleural effusions caused by malignant mesothelioma or primary lung cancer.

J Maeda1, N Ueki, T Ohkawa, N Iwahashi, T Nakano, T Hada, K Higashino.   

Abstract

We investigated the levels of TGF-beta in malignant pleural effusions (MPE) caused by malignant mesothelioma (MESO) or primary lung cancer. TGF-beta levels in MPE caused by MESO were 283.9 +/- 219.2 pm (mean +/- s.d.) and were three to six times higher than those due to primary lung cancers (P < 0.01 or P < 0.05). We also evaluated TGF-beta 1- and beta 2-like activities in MPE using specific polyclonal antibodies. Although TGF-beta 1-like activity could be detected in all cases, TGF-beta 2-like activities were detected in five of seven in MESO and in a few cases with primary lung cancer. These results demonstrate that the levels of total TGF-beta and TGF-beta 2-like activity may be clinically useful to differentiate MESO from primary lung cancer. Our data also suggest that TGF-beta may help further characterize the clinical features of MESO.

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Year:  1994        PMID： 7955539      PMCID： PMC1534420          DOI： 10.1111/j.1365-2249.1994.tb06144.x

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  23 in total

1.  Comparison of production of transforming growth factor-beta and platelet-derived growth factor by normal human mesothelial cells and mesothelioma cell lines.

Authors:  B I Gerwin; J F Lechner; R R Reddel; A B Roberts; K C Robbins; E W Gabrielson; C C Harris
Journal:  Cancer Res       Date:  1987-12-01       Impact factor: 12.701

2.  Immunodetection and quantitation of the two forms of transforming growth factor-beta (TGF-beta 1 and TGF-beta 2) secreted by cells in culture.

Authors:  D Danielpour; L L Dart; K C Flanders; A B Roberts; M B Sporn
Journal:  J Cell Physiol       Date:  1989-01       Impact factor: 6.384

3.  Transforming growth factor beta stimulates mammary adenocarcinoma cell invasion and metastatic potential.

Authors:  D R Welch; A Fabra; M Nakajima
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

4.  The expression of the platelet-derived and transforming growth factor genes in human nonsmall lung cancer cell lines is related to tumor stroma formation in nude mice tumors.

Authors:  J Bergh
Journal:  Am J Pathol       Date:  1988-12       Impact factor: 4.307

5.  Stimulation of DNA synthesis in cultured primary human mesothelial cells by specific growth factors.

Authors:  E W Gabrielson; B I Gerwin; C C Harris; A B Roberts; M B Sporn; J F Lechner
Journal:  FASEB J       Date:  1988-08       Impact factor: 5.191

6.  Human transforming growth factor type beta 2: production by a prostatic adenocarcinoma cell line, purification, and initial characterization.

Authors:  T Ikeda; M N Lioubin; H Marquardt
Journal:  Biochemistry       Date:  1987-05-05       Impact factor: 3.162

7.  Local production and localization of transforming growth factor-beta in tuberculous pleurisy.

Authors:  J Maeda; N Ueki; T Ohkawa; N Iwahashi; T Nakano; T Hada; K Higashino
Journal:  Clin Exp Immunol       Date:  1993-04       Impact factor: 4.330

8.  Mesoderm induction in amphibians: the role of TGF-beta 2-like factors.

Authors:  F Rosa; A B Roberts; D Danielpour; L L Dart; M B Sporn; I B Dawid
Journal:  Science       Date:  1988-02-12       Impact factor: 47.728

9.  Regulation of proliferation and differentiation of respiratory tract epithelial cells by TGF beta.

Authors:  A M Jetten; J E Shirley; G Stoner
Journal:  Exp Cell Res       Date:  1986-12       Impact factor: 3.905

10.  Differential expression of platelet-derived growth factor and transforming growth factor genes in small- and non-small-cell human lung carcinoma lines.

Authors:  G Söderdahl; C Betsholtz; A Johansson; K Nilsson; J Bergh
Journal:  Int J Cancer       Date:  1988-04-15       Impact factor: 7.396
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  12 in total

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2.  A novel transforming growth factor beta2 antisense transcript in mammalian lung.

Authors:  R K Coker; G J Laurent; K Dabbagh; J Dawson; R J McAnulty
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3.  Targeting mesothelioma using an infectivity enhanced survivin-conditionally replicative adenoviruses.

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Review 4.  Th17 cells and their related cytokines: vital players in progression of malignant pleural effusion.

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5.  Immunological changes in mesothelioma patients and their experimental detection.

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Journal:  Clin Med Circ Respirat Pulm Med       Date:  2008-03-26

6.  Pericardial cytokines in neoplastic, autoreactive, and viral pericarditis.

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Review 7.  Imaging in pleural mesothelioma: A review of the 13th International Conference of the International Mesothelioma Interest Group.

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8.  Immunohistochemical localization of transforming growth factor beta isoforms in asbestos-related diseases.

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Review 9.  Tumor Immune Microenvironment and Genetic Alterations in Mesothelioma.

Authors:  Stefanie Hiltbrunner; Laura Mannarino; Michaela B Kirschner; Isabelle Opitz; Angelica Rigutto; Alexander Laure; Michela Lia; Paolo Nozza; Antonio Maconi; Sergio Marchini; Maurizio D'Incalci; Alessandra Curioni-Fontecedro; Federica Grosso
Journal:  Front Oncol       Date:  2021-06-23       Impact factor: 6.244

10.  Convergent signaling in the regulation of connective tissue growth factor in malignant mesothelioma: TGFβ signaling and defects in the Hippo signaling cascade.

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Journal:  Cell Cycle       Date:  2012-08-23       Impact factor: 4.534
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