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Literature DB >> 795425

A model for cytoplasm-governed gene regulation.

Abstract

A model of cytoplasm-governed transcription is presented. The nuclear membrane has a selective permeability towards nuclear pre-mRNA molecules which are provided with group-specific non-translated "passwords". RNA transcription on the chromatin proceeds under a dual control. One of them is gene regulation according to the Britten-Davidson and Georgiev models. The other is cytoplasm-governed regulation mediated through the selective transport of mRNA from nucleus to cytoplasm. Pre-mRNA molecules which are not "in immediate demand" by the cytoplasm and therefore accumulating the nucleus repress their own synthesis by end-product inhibition. The interrelationship of the two types of regulation in the course of cell development is discussed.

Mesh：

Substances：
Chromatin
RNA, Messenger

Year: 1976 PMID： 795425 PMCID： PMC1164182 DOI： 10.1042/bj1590783

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

111 in total

1. THE OPERON: ON ITS THIRD ANNIVERSARY. MODULATION OF TRANSFER RNA SPECIES CAN PROVIDE A WORKABLE MODEL OF AN OPERATOR-LESS OPERON.

Authors: G S STENT
Journal: Science Date: 1964-05-15 Impact factor: 47.728

2. The isolation of DNA-like RNA and ribosomal RNA from the nucleolo-chromosomal apparatus of mammalian cells.

Authors: G P GEORGIEV; V L MANTIEVA
Journal: Biochim Biophys Acta Date: 1962-07-09

3. Turnover of nuclear and cytoplasmic ribonucleic acid in two types of animal cell, with some further observations on the nucleolus.

Authors: H HARRIS
Journal: Biochem J Date: 1959-10 Impact factor: 3.857

4. Sedimentation characteristics of rapidly labelled RNA from HeLa cells.

Authors: K SCHERRER; J E DARNELL
Journal: Biochem Biophys Res Commun Date: 1962-06-04 Impact factor: 3.575

5. Control of specific gene expression in higher organisms. Expression of mammalian genes may be controlled by repressors acting on the translation of messenger RNA.

Authors: G M Tomkins; T D Gelehrter; D Granner; D Martin; H H Samuels; E B Thompson
Journal: Science Date: 1969-12-19 Impact factor: 47.728

1. A comparative study of the early effects of phenobarbital and 3-methylcholanthrene on the synthesis and transport of ribonucleic acid in rat liver.

Authors: A Kumar; M R Rao; G Padmanaban
Journal: Biochem J Date: 1980-01-15 Impact factor: 3.857

2. Effect of cytosol on transport of RNA in vitro during cardiac hypertrophy.

Authors: S Meenakshi; C Thirunavukkarasu; C Rajamanickam
Journal: Biochem J Date: 1983-02-01 Impact factor: 3.857

2 in total

A model for cytoplasm-governed gene regulation.

1. THE OPERON: ON ITS THIRD ANNIVERSARY. MODULATION OF TRANSFER RNA SPECIES CAN PROVIDE A WORKABLE MODEL OF AN OPERATOR-LESS OPERON.

2. The isolation of DNA-like RNA and ribosomal RNA from the nucleolo-chromosomal apparatus of mammalian cells.

3. Turnover of nuclear and cytoplasmic ribonucleic acid in two types of animal cell, with some further observations on the nucleolus.

4. Sedimentation characteristics of rapidly labelled RNA from HeLa cells.

5. Control of specific gene expression in higher organisms. Expression of mammalian genes may be controlled by repressors acting on the translation of messenger RNA.

6. Nucleotide metabolism. I. The conversion of orotic acid-6-C14 to uridine nucleotides.

7. ATP requirement for release of adenovirus mRNA from isolated nuclei.

8. Localisation of rapidly and slowly labelled nuclear RNA as visualized by high resolution autoradiography.

9. Synthesis and processing of nuclear precursor-messenger RNA in avian erythroblasts and HeLa cells.

10. Synthesis of messenger RNA and chromosome structure in the cellular slime mold.

1. A comparative study of the early effects of phenobarbital and 3-methylcholanthrene on the synthesis and transport of ribonucleic acid in rat liver.

2. Effect of cytosol on transport of RNA in vitro during cardiac hypertrophy.