Literature DB >> 7953712

Site-specific hippocampal pathophysiology due to cerebral overexpression of interleukin-6 in transgenic mice.

S C Steffensen1, I L Campbell, S J Henriksen.   

Abstract

Transgenic mice expressing the cytokine interleukin-6 exhibit distinctive hippocampal interneuron pathology and behavioral seizures. Electroencephalographic recordings from these mice revealed anomalous hippocampal paroxysmal discharges and suppressed theta rhythm. Analysis of hippocampal field responses evoked by monosynaptic afferent stimulation revealed a site-specific increase in recurrent inhibition in the dentate gyrus. In addition, the cholinergic component of septohippocampal conditioning of dentate-evoked activity was absent in the transgenic mice. These results indicate that overexpression of interleukin-6 selectively disrupts cholinergic transmission by inducing a functional pathophysiology of hippocampal cholinoceptive target neurons.

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Year:  1994        PMID： 7953712     DOI： 10.1016/0006-8993(94)90329-8

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  21 in total

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Review 9.  Transgenic models for cytokine-induced neurological disease.

Authors:  Iain L Campbell; Markus J Hofer; Axel Pagenstecher
Journal:  Biochim Biophys Acta       Date:  2009-10-14

Review 10.  Role of brain inflammation in epileptogenesis.

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