Literature DB >> 7953600

Cerebellar agenesis.

M Glickstein1.   

Abstract

Lesions of the cerebellum produce profound deficits in movement. Since there is demonstrable recovery from partial lesions, some have asserted that the cerebellum may not be necessary for normal movement. It is even alleged that people may not manifest any motor symptoms despite total cerebellar agenesis. The literature points to a different conclusion. Cerebellar agenesis is always associated with profound motor deficits. A case of cerebellar agenesis of a man who died in 1951 is discussed. Evidence is presented that it is this case which gave rise to part of the oral tradition which alleges that normal movement is possible despite total cerebellar agenesis. In this brain an MRI scan revealed a small residual cerebellum. Moreover, despite an oral tradition to the contrary, there is absolutely no evidence about the motor capacities of this man during his life.

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Year:  1994        PMID: 7953600     DOI: 10.1093/brain/117.5.1209

Source DB:  PubMed          Journal:  Brain        ISSN: 0006-8950            Impact factor:   13.501


  12 in total

1.  Complex I deficiency due to loss of Ndufs4 in the brain results in progressive encephalopathy resembling Leigh syndrome.

Authors:  Albert Quintana; Shane E Kruse; Raj P Kapur; Elisenda Sanz; Richard D Palmiter
Journal:  Proc Natl Acad Sci U S A       Date:  2010-06-01       Impact factor: 11.205

2.  Obsessive-Compulsive Symptoms in an Adolescent Appearing after Cerebellar Vermian Mass Resection.

Authors:  Harshal Sathe; Sagar Karia; Avinash De Sousa; Nilesh Shah
Journal:  J Clin Diagn Res       Date:  2016-05-01

3.  Control of voluntary and optogenetically perturbed locomotion by spike rate and timing of neurons of the mouse cerebellar nuclei.

Authors:  Rashmi Sarnaik; Indira M Raman
Journal:  Elife       Date:  2018-04-16       Impact factor: 8.140

Review 4.  Evolution of the Human Nervous System Function, Structure, and Development.

Authors:  André M M Sousa; Kyle A Meyer; Gabriel Santpere; Forrest O Gulden; Nenad Sestan
Journal:  Cell       Date:  2017-07-13       Impact factor: 41.582

5.  A new case of complete primary cerebellar agenesis: clinical and imaging findings in a living patient.

Authors:  Feng Yu; Qing-jun Jiang; Xi-yan Sun; Rong-wei Zhang
Journal:  Brain       Date:  2014-08-22       Impact factor: 13.501

6.  The Woman Born Without a Cerebellum: A Real-Life Case Adapted for Use in an Undergraduate Developmental and Systems Neuroscience Course.

Authors:  Jennifer Brielmaier
Journal:  J Undergrad Neurosci Educ       Date:  2016-04-15

7.  Primary cerebellar agenesis presenting as isolated cognitive impairment.

Authors:  Obaid Ashraf; Shumyla Jabeen; Azhar Khan; Feroze Shaheen
Journal:  J Pediatr Neurosci       Date:  2016 Apr-Jun

Review 8.  The Neural Correlates of Consciousness and Attention: Two Sister Processes of the Brain.

Authors:  Andrea Nani; Jordi Manuello; Lorenzo Mancuso; Donato Liloia; Tommaso Costa; Franco Cauda
Journal:  Front Neurosci       Date:  2019-10-31       Impact factor: 4.677

Review 9.  The neuropsychiatry of the cerebellum - insights from the clinic.

Authors:  Jeremy D Schmahmann; Jeffrey B Weilburg; Janet C Sherman
Journal:  Cerebellum       Date:  2007       Impact factor: 3.648

10.  Clinical and MRI findings of cerebellar agenesis in two living adult patients.

Authors:  Fazıl Mustafa Gelal; Tuğçe Özlem Kalaycı; Mehmet Çelebisoy; Levent Karakaş; Hülya Erdoğan Akkurt; Feray Koç
Journal:  Ann Indian Acad Neurol       Date:  2016 Apr-Jun       Impact factor: 1.383

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