Literature DB >> 7953572

YAC vectors. Humanizing the mouse genome.

A Jakobovits1.   

Abstract

The ability to replace mouse genes with their human equivalents using "yeast artificial chromosome" technology provides a powerful new technique for studying the regulation and function of human genes.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 7953572     DOI： 10.1016/s0960-9822(00)00172-x

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  3 in total

1.  Double trans-chromosomic mice: maintenance of two individual human chromosome fragments containing Ig heavy and kappa loci and expression of fully human antibodies.

Authors:  K Tomizuka; T Shinohara; H Yoshida; H Uejima; A Ohguma; S Tanaka; K Sato; M Oshimura; I Ishida
Journal:  Proc Natl Acad Sci U S A       Date:  2000-01-18       Impact factor: 11.205

Review 2.  Size matters: use of YACs, BACs and PACs in transgenic animals.

Authors:  P Giraldo; L Montoliu
Journal:  Transgenic Res       Date:  2001-04       Impact factor: 2.788

3.  Crystal structure reveals conservation of amyloid-β conformation recognized by 3D6 following humanization to bapineuzumab.

Authors:  Hadar Feinberg; José W Saldanha; Linnea Diep; Amita Goel; Angela Widom; Geertruida M Veldman; William I Weis; Dale Schenk; Guriqbal S Basi
Journal:  Alzheimers Res Ther       Date:  2014-06-02       Impact factor: 6.982
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.