Literature DB >> 7951319

A dosage sensitive locus at chromosome Xp21 is involved in male to female sex reversal.

B Bardoni1, E Zanaria, S Guioli, G Floridia, K C Worley, G Tonini, E Ferrante, G Chiumello, E R McCabe, M Fraccaro.   

Abstract

Male to female sex reversal has been observed in individuals with duplications of the short arm of the X chromosome. Here we demonstrate that sex reversal results from the presence of two active copies of an Xp locus rather than from its rearrangement and that alterations at this locus constitute one of the causes of sex reversal in individuals with a normal 46,XY karyotype. We have named this locus DSS (Dosage Sensitive Sex reversal) and localized it to a 160 kilobase region of chromosome Xp21, adjacent to the adrenal hypoplasia congenita locus. The identification of male individuals deleted for DSS suggests that this locus is not required for testis differentiation. We propose that DSS has a role in ovarian development and/or functions as a link between ovary and testis formation.

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Year:  1994        PMID： 7951319     DOI： 10.1038/ng0894-497

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  71 in total

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