Literature DB >> 7951166

Castration lowers and testosterone restores blood pressure in several rat strains on high sodium diets.

C Jenkins1, R Salisbury, D Ely.   

Abstract

The objective of this study was to determine the effect of a high sodium diet and prepubertal castration (5-6 weeks) and androgen replacement therapy on blood pressure in male normotensive, borderline hypertensive and hypertensive rats on a high sodium diet between 9-22 weeks of age. The strains used were: Wistar Kyoto-(WKY), spontaneously hypertensive rat-(SHR), and borderline hypertensive rat-(BHR). Castration significantly reduced blood pressure (20-30 mmHg) and testosterone replacement in castrated males restored blood pressure in all strains. Plasma norepinephrine (NE) increased with castration in the WKY and SHR strains but decreased in the BHR. However, there was a significant elevation in all strains between the midpoint and endpoint NE values. The high sodium diet did not prevent the blood pressure lowering effect of castration.

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Year:  1994        PMID： 7951166     DOI： 10.3109/10641969409067965

Source DB:  PubMed          Journal:  Clin Exp Hypertens        ISSN： 1064-1963            Impact factor:   1.749


  9 in total

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2.  Enhanced mesenteric arterial responsiveness to angiotensin II is androgen receptor-dependent in prenatally protein-restricted adult female rat offspring.

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4.  Strategies and methods to study sex differences in cardiovascular structure and function: a guide for basic scientists.

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Review 5.  Androgen Effects on the Adrenergic System of the Vascular, Airway, and Cardiac Myocytes and Their Relevance in Pathological Processes.

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6.  A cell culture model using rat coronary artery adventitial fibroblasts to measure collagen production.

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Review 7.  Androgen therapy and atherosclerotic cardiovascular disease.

Authors:  K-C Y McGrath; L S McRobb; A K Heather
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8.  Testosterone influences renal electrolyte excretion in SHR/y and WKY males.

Authors:  Jonathan Toot; Cathy Jenkins; Gail Dunphy; Shannon Boehme; Mike Hart; Amy Milsted; Monte Turner; Daniel Ely
Journal:  BMC Physiol       Date:  2008-03-26

9.  In utero origin of sex-related differences in future cardiovascular disease.

Authors:  Sarah Schalekamp-Timmermans; Jerome Cornette; Albert Hofman; Willem A Helbing; Vincent W V Jaddoe; Eric A P Steegers; Bero O Verburg
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  9 in total

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