Literature DB >> 7949335

Detection of 500-nucleotide DNA by laser desorption mass spectrometry.

K Tang1, N I Taranenko, S L Allman, L Y Cháng, C H Chen.   

Abstract

We report the first detection of DNA segments as large as 500 nucleotides by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry, using picolinic acid and 3-hydroxypicolinic acid mixtures as desorption matrices. The successful detection of 500-nucleotide DNA indicates that laser mass spectrometry is now emerging as a new biotechnology tool for DNA-related research. It should be possible to utilize fast detection of large DNA segments by laser mass spectrometry for rapid human genome sequencing.

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Year:  1994        PMID： 7949335     DOI： 10.1002/rcm.1290080913

Source DB:  PubMed          Journal:  Rapid Commun Mass Spectrom        ISSN： 0951-4198            Impact factor:   2.419


  14 in total

1.  Identification of single stranded regions of DNA by enzymatic digestion with matrix-assisted laser desorption/ionization analysis.

Authors:  W P Bartolini; C M Bentzley; M V Johnston; B S Larsen
Journal:  J Am Soc Mass Spectrom       Date:  1999-06       Impact factor: 3.109

2.  Mass spectrometry of single-stranded restriction fragments captured by an undigested complementary sequence.

Authors:  N H Chiu; K Tang; P Yip; A Braun; H Koster; C R Cantor
Journal:  Nucleic Acids Res       Date:  2000-04-15       Impact factor: 16.971

3.  Fragmentation pathway studies of oligonucleotides in matrix-assisted laser desorption/ionization mass spectrometry by charge tagging and H/D exchange.

Authors:  Chau-Wen Chou; Patrick A Limbach; Richard B Cole
Journal:  J Am Soc Mass Spectrom       Date:  2002-12       Impact factor: 3.109

Review 4.  MALDI-TOF mass spectrometry: a versatile tool for high-performance DNA analysis.

Authors:  Christian Jurinke; Paul Oeth; Dirk van den Boom
Journal:  Mol Biotechnol       Date:  2004-02       Impact factor: 2.695

Review 5.  Mass spectrometric imaging for biomedical tissue analysis.

Authors:  Kamila Chughtai; Ron M A Heeren
Journal:  Chem Rev       Date:  2010-05-12       Impact factor: 60.622

6.  Heterobifunctional modification of DNA for conjugation to solid surfaces.

Authors:  Hana I Lim; Piercen M Oliver; Jutta Marzillier; Dmitri V Vezenov
Journal:  Anal Bioanal Chem       Date:  2010-04-28       Impact factor: 4.142

7.  DNA sequencing by delayed extraction-matrix-assisted laser desorption/ionization time of flight mass spectrometry.

Authors:  M T Roskey; P Juhasz; I P Smirnov; E J Takach; S A Martin; L A Haff
Journal:  Proc Natl Acad Sci U S A       Date:  1996-05-14       Impact factor: 11.205

8.  Sequencing DNA using mass spectrometry for ladder detection.

Authors:  N I Taranenko; S L Allman; V V Golovlev; N V Taranenko; N R Isola; C H Chen
Journal:  Nucleic Acids Res       Date:  1998-05-15       Impact factor: 16.971

9.  Elucidation of the initial step of oligonucleotide fragmentation in matrix-assisted laser desorption/ionization using modified nucleic acids.

Authors:  N P Christian; J P Reilly; V R Mokler; F E Wincott; A D Ellington
Journal:  J Am Soc Mass Spectrom       Date:  2001-06       Impact factor: 3.109

10.  The detection of intact double-stranded DNA by MALDI.

Authors:  P Lecchi; L K Pannell
Journal:  J Am Soc Mass Spectrom       Date:  1995-10       Impact factor: 3.109
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