Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The yin and yang of p53 in cellular proliferation.

Literature DB >> 7948947

The yin and yang of p53 in cellular proliferation.

Abstract

The tumor suppressor p53 is a key element in preserving the stability of the genetic information of vertebrates. In response to DNA damage, PSS induces a growth arrest thus allowing time for DNA repair to occur. However, p53 seems to exert additional functions in cellular proliferation, amongst them a so far unidentified role in the progression of cells through the cell cycle and in differentiation processes. Modulation of p53 activities, by regulating p53 interactions with different target genes and cellular protein partners through the cellular environment might explain the diversity of p53 functions in cellular growth control.

Entities: Disease Gene

Mesh：

Substances：

Year: 1994 PMID： 7948947

Source DB: PubMed Journal: Semin Cancer Biol ISSN： 1044-579X Impact factor: 15.707

Keyword Cloud
Cited

11 in total

Review 1. Regulation of p53 by protein kinase C during multi-stage carcinogenesis.

Authors: L Magnelli; V Chiarugi
Journal: J Cancer Res Clin Oncol Date: 1997 Impact factor: 4.553

2. Meningiomas in Singapore: demographic and biological characteristics.

Authors: A Das; W Y Tang; D R Smith
Journal: J Neurooncol Date: 2000-04 Impact factor: 4.130

3. Germ cell tumors of the testis overexpress wild-type p53.

Authors: L Guillou; A Estreicher; P Chaubert; J Hurlimann; A M Kurt; G Metthez; R Iggo; A C Gray; P Jichlinski; H J Leisinger; J Benhattar
Journal: Am J Pathol Date: 1996-10 Impact factor: 4.307

4. Species- and tissue-specific expression of the C-terminal alternatively spliced form of the tumor suppressor p53.

Authors: K Will; G Warnecke; S Bergmann; W Deppert
Journal: Nucleic Acids Res Date: 1995-10-25 Impact factor: 16.971

5. Cooperation of simian virus 40 large and small T antigens in metabolic stabilization of tumor suppressor p53 during cellular transformation.

Authors: F Tiemann; J Zerrahn; W Deppert
Journal: J Virol Date: 1995-10 Impact factor: 5.103

10. Losses of expression of the antigens A, Lea and Lex and over-expression of Ley in carcinomas and HG-SIL of the uterine cervix.

Authors: Ernesto Moro-Rodríguez; Emilio Alvarez-Fernández
Journal: Diagn Pathol Date: 2008-09-11 Impact factor: 2.644

The yin and yang of p53 in cellular proliferation.

Review 1. Regulation of p53 by protein kinase C during multi-stage carcinogenesis.

2. Meningiomas in Singapore: demographic and biological characteristics.

3. Germ cell tumors of the testis overexpress wild-type p53.

4. Species- and tissue-specific expression of the C-terminal alternatively spliced form of the tumor suppressor p53.

5. Cooperation of simian virus 40 large and small T antigens in metabolic stabilization of tumor suppressor p53 during cellular transformation.

6. Simian virus 40 small t antigen activates the carboxyl-terminal transforming p53-binding domain of large T antigen.

7. Negative feedback regulation of wild-type p53 biosynthesis.

8. GRIM-1, a novel growth suppressor, inhibits rRNA maturation by suppressing small nucleolar RNAs.

9. p53 protein expression in nephroblastomas: a predictor of poor prognosis.

10. Losses of expression of the antigens A, Lea and Lex and over-expression of Ley in carcinomas and HG-SIL of the uterine cervix.