Literature DB >> 7947764

Crystal structure of a four-stranded intercalated DNA: d(C4).

L Chen1, L Cai, X Zhang, A Rich.   

Abstract

The crystal structure of d(C4) solved at 2.3-A resolution reveals a four-stranded molecule composed of two interdigitated or intercalated duplexes. The duplexes are held together by hemiprotonated cytosine-cytosine base pairs and are parallel stranded, but the two duplexes point in opposite directions. The molecule has a slow right-handed twist of 12.4 degrees between covalently linked cytosine base pairs, and the base stacking distance is 3.1 A. This is in general agreement with the NMR studies. A biological role for DNA in this conformation is suggested.

Entities:  

Keywords:  NASA Discipline Exobiology; Non-NASA Center

Mesh：

Substances：

Year:  1994        PMID： 7947764     DOI： 10.1021/bi00250a005

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  26 in total

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3.  Crystal structure of d(GCGAAAGCT) containing a parallel-stranded duplex with homo base pairs and an anti-parallel duplex with Watson-Crick base pairs.

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4.  Biophysical characterization of an ensemble of intramolecular i-motifs formed by the human c-MYC NHE III1 P1 promoter mutant sequence.

Authors:  Jamie M Dettler; Robert Buscaglia; Jingjing Cui; Derek Cashman; Meredith Blynn; Edwin A Lewis
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Review 5.  Artificial Molecular Machines.

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6.  Base-tetrad swapping results in dimerization of RNA quadruplexes: implications for formation of the i-motif RNA octaplex.

Authors:  Baocheng Pan; Ke Shi; Muttaiya Sundaralingam
Journal:  Proc Natl Acad Sci U S A       Date:  2006-02-21       Impact factor: 11.205

7.  Inter-strand C-H...O hydrogen bonds stabilizing four-stranded intercalated molecules: stereoelectronic effects of O4' in cytosine-rich DNA.

Authors:  I Berger; M Egli; A Rich
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-29       Impact factor: 11.205

8.  Ultrafast excited-state dynamics of RNA and DNA C tracts.

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Journal:  Chem Phys       Date:  2008-06       Impact factor: 2.348

9.  Structural studies of a stable parallel-stranded DNA duplex incorporating isoguanine:cytosine and isocytosine:guanine basepairs by nuclear magnetic resonance spectroscopy.

Authors:  X L Yang; H Sugiyama; S Ikeda; I Saito; A H Wang
Journal:  Biophys J       Date:  1998-09       Impact factor: 4.033

10.  The i-motif in the bcl-2 P1 promoter forms an unexpectedly stable structure with a unique 8:5:7 loop folding pattern.

Authors:  Samantha Kendrick; Yoshitsugu Akiyama; Sidney M Hecht; Laurence H Hurley
Journal:  J Am Chem Soc       Date:  2009-12-09       Impact factor: 15.419
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