Literature DB >> 7947285

Myelodysplasia following paroxysmal nocturnal haemoglobinuria: evidence for the emergence of a separate clone.

H van Kamp1, J W Smit, E van den Berg, M Ruud Halie, E Vellenga.   

Abstract

A patient with paroxysmal nocturnal haemoglobinuria (PNH) who developed a myelodysplastic syndrome (MDS) is described. After the onset of myelodysplasia the neutrophils of the patient fully expressed GPI-linked proteins. It is concluded that the myelodysplasia does not originate from transformed PNH stem cells, but represents the emergence of a separate clone arising from an injured marrow.

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Year:  1994        PMID: 7947285     DOI: 10.1111/j.1365-2141.1994.tb04929.x

Source DB:  PubMed          Journal:  Br J Haematol        ISSN: 0007-1048            Impact factor:   6.998


  3 in total

Review 1.  Clinical manifestations of paroxysmal nocturnal hemoglobinuria: present state and future problems.

Authors:  Wendell F Rosse; Junichi Nishimura
Journal:  Int J Hematol       Date:  2003-02       Impact factor: 2.490

2.  Acute myelogenous leukemia with PIG-A gene mutation evolved from aplastic anemia-paroxysmal nocturnal hemoglobinuria syndrome.

Authors:  H Tanaka; N Imamura; N Oguma; T Shintani; K Tanaka; H Hyodo; K Oda; A Kimura
Journal:  Int J Hematol       Date:  2001-02       Impact factor: 2.490

3.  Paroxysmal nocturnal hemoglobinuria clone in a case of myelodysplastic syndrome rapidly progressing to acute leukemia.

Authors:  Swati Srivastava; Shano Naseem; Ritu Gupta; Rajesh Kashyap; Rajender Chaudhary
Journal:  Indian J Hematol Blood Transfus       Date:  2009-04-06       Impact factor: 0.900

  3 in total

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