Literature DB >> 7947102

The effect of 5-fluorouracil and alpha interferon and 5-fluorouracil and leucovorin on cellular anti-tumour immune responses in patients with advanced colorectal cancer.

P H Nichols1, U Ward, C W Ramsden, J N Primrose.   

Abstract

Interferon alpha (IFN-alpha) enhances the activity of 5-fluorouracil (5-FU) in the treatment of advanced colorectal cancer although the mechanism is not understood. We have investigated the effect of this combination on cellular immunity and compared this with standard therapy of 5-FU/L-leucovorin, in 24 patients with advanced colorectal cancer. This study has demonstrated an enhancement of the cellular immune response in patients given 5-FU/IFN-alpha with augmentation of natural killer (NK) cell function and abrogation of 5-FU-induced suppression of lymphokine-activated killer (LAK) cell activity.

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Year:  1994        PMID： 7947102      PMCID： PMC2033527          DOI： 10.1038/bjc.1994.426

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  13 in total

1.  Analysis of serial measurements in medical research.

Authors:  J N Matthews; D G Altman; M J Campbell; P Royston
Journal:  BMJ       Date:  1990-01-27

Review 2.  Interferon therapy in cancer: from imaginon to interferon.

Authors:  D Goldstein; J Laszlo
Journal:  Cancer Res       Date:  1986-09       Impact factor: 12.701

3.  Cytotoxic reactivity of human lymphocytes cultured in vitro.

Authors:  J R Ortaldo; G D Bonnard; R B Herberman
Journal:  J Immunol       Date:  1977-10       Impact factor: 5.422

4.  The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma: a prospective randomized phase III trial. Gastrointestinal Tumor Study Group.

Authors:  N Petrelli; H O Douglass; L Herrera; D Russell; D M Stablein; H W Bruckner; R J Mayer; R Schinella; M D Green; F M Muggia
Journal:  J Clin Oncol       Date:  1989-10       Impact factor: 44.544

Review 5.  Biochemical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma.

Authors:  M A Poon; M J O'Connell; C G Moertel; H S Wieand; S A Cullinan; L K Everson; J E Krook; J A Mailliard; J A Laurie; L K Tschetter
Journal:  J Clin Oncol       Date:  1989-10       Impact factor: 44.544

6.  Fluorouracil and recombinant alfa-2a-interferon: an active regimen against advanced colorectal carcinoma.

Authors:  S Wadler; E L Schwartz; M Goldman; A Lyver; M Rader; M Zimmerman; L Itri; V Weinberg; P H Wiernik
Journal:  J Clin Oncol       Date:  1989-12       Impact factor: 44.544

7.  Pharmacokinetics of 5-fluorouracil in colorectal cancer patients receiving interferon.

Authors:  K Pittman; T Perren; U Ward; J Primrose; M Slevin; N Patel; P Selby
Journal:  Ann Oncol       Date:  1993-06       Impact factor: 32.976

8.  A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma.

Authors:  C Erlichman; S Fine; A Wong; T Elhakim
Journal:  J Clin Oncol       Date:  1988-03       Impact factor: 44.544

9.  A pilot study of interferon alfa-2a in combination with fluorouracil plus high-dose leucovorin in metastatic gastrointestinal carcinoma.

Authors:  J L Grem; N McAtee; R F Murphy; F M Balis; S M Steinberg; J M Hamilton; J M Sorensen; O Sartor; B S Kramer; L J Goldstein
Journal:  J Clin Oncol       Date:  1991-10       Impact factor: 44.544

10.  Decreased interleukin-2 production in patients with gastrointestinal cancer.

Authors:  J R Monson; C Ramsden; P J Guillou
Journal:  Br J Surg       Date:  1986-06       Impact factor: 6.939
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  4 in total

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Review 3.  Autophagic Mechanism in Anti-Cancer Immunity: Its Pros and Cons for Cancer Therapy.

Authors:  Ying-Ying Li; Lynn G Feun; Angkana Thongkum; Chiao-Hui Tu; Shu-Mei Chen; Medhi Wangpaichitr; Chunjing Wu; Macus T Kuo; Niramol Savaraj
Journal:  Int J Mol Sci       Date:  2017-06-19       Impact factor: 5.923

4.  Identification of an Autophagy-Related Gene Signature for the Prediction of Prognosis in Early-Stage Colorectal Cancer.

Authors:  Xu-Tao Lin; Qiu-Ning Wu; Si Qin; De-Jun Fan; Min-Yi Lv; Xi Chen; Jia-Wei Cai; Jing-Rong Weng; Yi-Feng Zou; Yu-Ming Rong; Feng Gao
Journal:  Front Genet       Date:  2021-11-25       Impact factor: 4.599
  4 in total

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