Literature DB >> 7947046

Pediatric clinical use of the ketoconazole/cyclosporin interaction.

M Berkovitch1, M Bitzan, D Matsui, H Finkelstein, J W Balfe, G Koren.   

Abstract

Ketoconazole is known to inhibit the metabolism of cyclosporin through inhibition of cytochrome P-450. This pharmacological interaction was used in an 8-year-old renal transplant patient to successfully achieve therapeutic cyclosporin blood concentrations. The addition of ketoconazole to the cyclosporin regimen should be considered when difficulties are encountered in attaining satisfactory cyclosporin levels.

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Year:  1994        PMID： 7947046     DOI： 10.1007/bf00856546

Source DB:  PubMed          Journal:  Pediatr Nephrol        ISSN： 0931-041X            Impact factor:   3.714


  6 in total

1.  Concomitant administration of cyclosporin and ketoconazole in renal transplant recipients.

Authors:  M R First; T J Schroeder; P Weiskittel; S A Myre; J W Alexander; A J Pesce
Journal:  Lancet       Date:  1989-11-18       Impact factor: 79.321

2.  Safety and efficacy of long-term cyclosporine-ketoconazole administration and preliminary results of a randomized trial.

Authors:  M R First; T J Schroeder; A Michael; S Hariharan; P Weiskittel; J W Alexander
Journal:  Transplant Proc       Date:  1993-02       Impact factor: 1.066

3.  Effect of ketoconazole on hepatic oxidative drug metabolism.

Authors:  M W Brown; A L Maldonado; C G Meredith; K V Speeg
Journal:  Clin Pharmacol Ther       Date:  1985-03       Impact factor: 6.875

4.  Comparison of three immunosuppressive regimens in cadaver renal transplantation: long-term cyclosporine, short-term cyclosporine followed by azathioprine and prednisolone, and azathioprine and prednisolone without cyclosporine.

Authors:  B M Hall; D J Tiller; I Hardie; J Mahony; T Mathew; G Thatcher; P Miach; N Thomson; A G Sheil
Journal:  N Engl J Med       Date:  1988-06-09       Impact factor: 91.245

Review 5.  Practical aspects in the use of cyclosporin in paediatric nephrology.

Authors:  P F Hoyer; J Brodehl; J H Ehrich; G Offner
Journal:  Pediatr Nephrol       Date:  1991-09       Impact factor: 3.714

6.  Cyclosporine dose reduction by ketoconazole administration in renal transplant recipients.

Authors:  M R First; T J Schroeder; J W Alexander; G W Stephens; P Weiskittel; S A Myre; A J Pesce
Journal:  Transplantation       Date:  1991-02       Impact factor: 4.939
  6 in total
  3 in total

1.  Impact of the cyclosporine-ketoconazole interaction in children with steroid-dependent idiopathic nephrotic syndrome.

Authors:  Amr El-Husseini; Fathy El-Basuony; Ihab Mahmoud; Ahmed Donia; Hussein Sheashaa; Alaa Sabry; Nabil Hassan; Nagy Sayed-Ahmad; Mohamed Sobh
Journal:  Eur J Clin Pharmacol       Date:  2005-12-23       Impact factor: 2.953

2.  Co-administration of cyclosporine and ketoconazole in idiopathic childhood nephrosis.

Authors:  Amr el-Husseini; Fathy el-Basuony; Ihab Mahmoud; Ahmed Donia; Nabil Hassan; Nagy Sayed-Ahmad; Mohamed Sobh
Journal:  Pediatr Nephrol       Date:  2004-07-06       Impact factor: 3.714

3.  Cyclosporine/ketoconazole reduces treatment costs for nephrotic syndrome.

Authors:  A Iyengar; N Kamath; K D Phadke; M Bitzan
Journal:  Indian J Nephrol       Date:  2013-11
  3 in total

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