Literature DB >> 7947019

Interference of high-dose methotrexate in the metabolism of valproate?

H Schrøder1, J R Ostergaard.   

Abstract

A case of tonic-clonic seizure was observed in a child with acute lymphoblastic leukemia a few hours after a 24-hour infusion of high-dose methotrexate (MTX; 5 g/m2). Because of former epileptic symptoms, the child had been treated with valproic acid for several months. During this and the following high-dose MTX infusion, an acute decline of the serum valproate concentration to about 25% of the pre-MTX value was observed. The pathogenesis of the acute decline of serum valproate concentration is discussed.

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Year:  1994        PMID： 7947019     DOI： 10.3109/08880019409140546

Source DB:  PubMed          Journal:  Pediatr Hematol Oncol        ISSN： 0888-0018            Impact factor:   1.969


  3 in total

1.  Pharmacokinetic interaction on valproic acid and recurrence of epileptic seizures during chemotherapy in an epileptic patient.

Authors:  Hiroaki Ikeda; Teruo Murakami; Mikihisa Takano; Tsuguru Usui; Kenji Kihira
Journal:  Br J Clin Pharmacol       Date:  2005-05       Impact factor: 4.335

2.  Pharmacogenetics of the Central Nervous System-Toxicity and Relapse Affecting the CNS in Pediatric Acute Lymphoblastic Leukemia.

Authors:  Judit C Sági; András Gézsi; Bálint Egyed; Zsuzsanna Jakab; Noémi Benedek; Andishe Attarbaschi; Stefan Köhrer; Jakub Sipek; Lucie Winkowska; Marketa Zaliova; Stavroula Anastasopoulou; Benjamin Ole Wolthers; Susanna Ranta; Csaba Szalai; Gábor T Kovács; Ágnes F Semsei; Dániel J Erdélyi
Journal:  Cancers (Basel)       Date:  2021-05-12       Impact factor: 6.639

3.  Weekly methotrexate may reduce valproate levels causing relapse of genetic generalized epilepsy.

Authors:  Ajith Cherian; Sharath Chandra Shetty; K P Divya; Harini Pavuluri
Journal:  Epilepsy Behav Rep       Date:  2021-05-07
  3 in total

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