Literature DB >> 7946942

Absorption of ipsapirone along the human gastrointestinal tract.

U Fuhr1, A H Staib, S Harder, K Becker, D Liermann, G Schöllnhammer, I S Roed.   

Abstract

Isapirone-HCl (5 mg) was administered orally, rectally and locally, by a remote control drug delivery device (HF-capsule) into different segments of the gastrointestinal tract, to four young healthy male adults. The relative systemic bioavailability of the drug from the colon and rectum was 2-3-fold greater than that from the upper gastrointestinal tract. This supports a rationale for a prolonged-release formulation.

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Year:  1994        PMID： 7946942      PMCID： PMC1364843          DOI： 10.1111/j.1365-2125.1994.tb04327.x

Source DB:  PubMed          Journal:  Br J Clin Pharmacol        ISSN： 0306-5251            Impact factor:   4.335


  4 in total

1.  Ciprofloxacin absorption in different regions of the human gastrointestinal tract. Investigations with the hf-capsule.

Authors:  S Harder; U Fuhr; D Beermann; A H Staib
Journal:  Br J Clin Pharmacol       Date:  1990-07       Impact factor: 4.335

2.  Alterations of central serotoninergic and dopaminergic neurotransmission in rats chronically treated with ipsapirone: biochemical and electrophysiological studies.

Authors:  L E Schechter; F J Bolaños; H Gozlan; L Lanfumey; S Haj-Dahmane; A M Laporte; C M Fattaccini; M Hamon
Journal:  J Pharmacol Exp Ther       Date:  1990-12       Impact factor: 4.030

3.  Ipsapirone: evidence for efficacy in depression.

Authors:  A H Heller; M Beneke; B Kuemmel; D Spencer; N M Kurtz
Journal:  Psychopharmacol Bull       Date:  1990

4.  Efficacy and safety of a putative anxiolytic agent: ipsapirone.

Authors:  R L Borison; J W Albrecht; B I Diamond
Journal:  Psychopharmacol Bull       Date:  1990
  4 in total
  5 in total

1.  Meta-analysis of Magnetic Marker Monitoring Data to Characterize the Movement of Single Unit Dosage Forms Though the Gastrointestinal Tract Under Fed and Fasting Conditions.

Authors:  Emilie Hénin; Martin Bergstrand; Werner Weitschies; Mats O Karlsson
Journal:  Pharm Res       Date:  2015-11-09       Impact factor: 4.200

Review 2.  Clinical pharmacokinetics of trospium chloride.

Authors:  Oxana Doroshyenko; Alexander Jetter; Karl P Odenthal; Uwe Fuhr
Journal:  Clin Pharmacokinet       Date:  2005       Impact factor: 6.447

3.  Magnetically Actuated Soft Capsule With the Multimodal Drug Release Function.

Authors:  Sehyuk Yim; Kartik Goyal; Metin Sitti
Journal:  IEEE ASME Trans Mechatron       Date:  2013-01-03       Impact factor: 5.303

4.  Evaluation of the feasibility and use of a prototype remote drug delivery capsule (RDDC) for non-invasive regional drug absorption studies in the GI tract of man and beagle dog.

Authors:  A F Parr; E P Sandefer; P Wissel; M McCartney; C McClain; U Y Ryo; G A Digenis
Journal:  Pharm Res       Date:  1999-02       Impact factor: 4.200

Review 5.  The clinical pharmacokinetics of darifenacin.

Authors:  Andrej Skerjanec
Journal:  Clin Pharmacokinet       Date:  2006       Impact factor: 6.447
  5 in total

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