| Literature DB >> 7945781 |
L B Justement1, V K Brown, J Lin.
Abstract
Recent studies have demonstrated that the protein tyrosine phosphatase CD45 plays an integral role in regulation of B-cell function. Most notably, expression of this phosphatase is required for activation of B lymphocytes and entry into the cell cycle. Here, Louis Justement and colleagues review current information concerning the function of CD45 in the B cell. The discussion focuses on two questions that are of central importance: what are the physiological substrates for CD45 and how does reversible tyrosine phosphorylation affect their function?Entities:
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Year: 1994 PMID： 7945781 DOI： 10.1016/0167-5699(94)90268-2
Source DB: PubMed Journal: Immunol Today ISSN： 0167-5699