Literature DB >> 7945724

Probing the active site and mechanism of action of O6-methylguanine-DNA methyltransferase with substrate analogues (O6-substituted guanines).

C E Arris1, C Bleasdale, A H Calvert, N J Curtin, C Dalby, B T Golding, R J Griffin, J M Lunn, G N Major, D R Newell.   

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Year:  1994        PMID： 7945724

Source DB:  PubMed          Journal:  Anticancer Drug Des        ISSN： 0266-9536


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  5 in total

1.  Crystal structure of the human O(6)-alkylguanine-DNA alkyltransferase.

Authors:  J E Wibley; A E Pegg; P C Moody
Journal:  Nucleic Acids Res       Date:  2000-01-15       Impact factor: 16.971

2.  6-Oxo and 6-thio purine analogs as antimycobacterial agents.

Authors:  Ashish K Pathak; Vibha Pathak; Lainne E Seitz; William J Suling; Robert C Reynolds
Journal:  Bioorg Med Chem       Date:  2013-02-04       Impact factor: 3.641

3.  Recombinant human O6-alkylguanine-DNA alkyltransferase (AGT), Cys145-alkylated AGT and Cys145 --> Met145 mutant AGT: comparison by isoelectric focusing, CD and time-resolved fluorescence spectroscopy.

Authors:  M Federwisch; U Hassiepen; K Bender; M Dewor; M F Rajewsky; A Wollmer
Journal:  Biochem J       Date:  1997-05-15       Impact factor: 3.857

4.  Binding and repair of O6-ethylguanine in double-stranded oligodeoxynucleotides by recombinant human O6-alkylguanine-DNA alkyltransferase do not exhibit significant dependence on sequence context.

Authors:  K Bender; M Federwisch; U Loggen; P Nehls; M F Rajewsky
Journal:  Nucleic Acids Res       Date:  1996-06-01       Impact factor: 16.971

5.  Synthesis and quantitative structure-activity relationship of imidazotetrazine prodrugs with activity independent of O6-methylguanine-DNA-methyltransferase, DNA mismatch repair, and p53.

Authors:  Dimitrios Pletsas; Elrashied A E Garelnabi; Li Li; Roger M Phillips; Richard T Wheelhouse
Journal:  J Med Chem       Date:  2013-08-16       Impact factor: 7.446
  5 in total

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