Literature DB >> 7945718

Synthesis and in vitro anti-HIV activity of novel delta 2-1,2,4-oxadiazoline derivatives.

A Chimirri1, S Grasso, A M Monforte, P Monforte, M Zappalà, A Carotti.   

Abstract

The synthesis of 4-adamantyl-5-aryl-3-phenyl-delta 2-1,2,4-oxadiazolines, involving an 1,3-dipolar cycloaddition reaction between 1-[(arylidene)amino]adamantanes and benzonitriloxide, is described. The evaluation of in vitro antiviral activity against human immunodeficiency virus (HIV) of the compounds obtained is also reported.

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Year:  1994        PMID: 7945718

Source DB:  PubMed          Journal:  Farmaco        ISSN: 0014-827X


  2 in total

1.  2-[3-Acetyl-5-(2-chloro-3-pyrid-yl)-2-methyl-2,3-dihydro-1,3,4-oxadiazol-2-yl]-4-fluoro-phenyl acetate.

Authors:  Quan Qin; Li Juan Xu; Li Fang Pan; Shui Qing Chen; Qing Bao Song
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-04-30

2.  Synthesis, antimicrobial and antiviral testing of some new 1-adamantyl analogues.

Authors:  Ghada S Hassan; Ali A El-Emam; Laila M Gad; Alaa Eldin M Barghash
Journal:  Saudi Pharm J       Date:  2010-05-31       Impact factor: 4.330

  2 in total

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