| Literature DB >> 794557 |
N M Thomson, J Moran, I J Simpson, D K Peters.
Abstract
Defibrination with ancrod in nephrotoxic nephritis in rabbits. In rabbits with nephrotoxic nephritis, defibrination with ancrod provided protection when administered during the autologous phase, after extensive glomerular fibrin deposition had occurred and crescents and renal failure were developing. When further glomerular fibrin deposition was prevented by defibrination, deposited fibrin was rapidly removed, indicating that glomerular fibrin-clearing mechanisms are retained in crescentic nephritis. Defibrination had no effect on the extent of glomerular C3 deposition or on the amount of proteinuria.Entities:
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Year: 1976 PMID： 794557 DOI： 10.1038/ki.1976.120
Source DB: PubMed Journal: Kidney Int ISSN： 0085-2538 Impact factor: 10.612