OBJECTIVE: To assess whether the HLA-DR4 association found in rheumatoid arthritis (RA) is also seen in the large granular lymphocyte (LGL) syndrome. METHODS: HLA-DR genotyping was performed using restriction fragment length polymorphism and polymerase chain reaction analysis. RESULTS: LGL syndrome patients with RA showed the same HLA-DR4 association seen in RA/Felty's syndrome (FS), while LGL syndrome patients without arthritis did not. CONCLUSION: It is proposed that FS and the LGL syndrome represent different variants of a broader syndrome comprising RA, neutropenia, LGL expansions, HLA-DR4 positivity, and splenomegaly.
OBJECTIVE: To assess whether the HLA-DR4 association found in rheumatoid arthritis (RA) is also seen in the large granular lymphocyte (LGL) syndrome. METHODS: HLA-DR genotyping was performed using restriction fragment length polymorphism and polymerase chain reaction analysis. RESULTS:LGL syndromepatients with RA showed the same HLA-DR4 association seen in RA/Felty's syndrome (FS), while LGL syndromepatients without arthritis did not. CONCLUSION: It is proposed that FS and the LGL syndrome represent different variants of a broader syndrome comprising RA, neutropenia, LGL expansions, HLA-DR4 positivity, and splenomegaly.
Authors: S J Bowman; M Bhavnani; G C Geddes; V Corrigall; A W Boylston; G S Panayi; J S Lanchbury Journal: Clin Exp Immunol Date: 1995-07 Impact factor: 4.330
Authors: Paula Savola; Oscar Brück; Thomas Olson; Tiina Kelkka; Markku J Kauppi; Panu E Kovanen; Soili Kytölä; Tuulikki Sokka-Isler; Thomas P Loughran; Marjatta Leirisalo-Repo; Satu Mustjoki Journal: Haematologica Date: 2017-12-07 Impact factor: 9.941