OBJECTIVE: To identify the T lymphocytes that mediate disease in rheumatoid arthritis (RA). METHODS: A panel of monoclonal antibodies reactive with T cell receptor (TCR) V beta gene products was used to analyze the RA T cell repertoire. RESULTS: Of 5 TCR V beta gene products studied, only V beta 17-positive T cells were increased in peripheral blood and synovial fluid (SF) from RA patients, compared with controls (P < 0.01 and P = 0.0006, respectively). Thirty-one percent of the 49 RA SF samples and none of the 19 non-RA SF samples contained > 10% V beta 17-positive T cells. Activated (Tac-positive) T cells were enriched among V beta 17-positive synovial T cells. CONCLUSION: The selective increase of V beta 17-positive T cells suggests a role for those T cells in the pathogenesis of RA.
OBJECTIVE: To identify the T lymphocytes that mediate disease in rheumatoid arthritis (RA). METHODS: A panel of monoclonal antibodies reactive with T cell receptor (TCR) V beta gene products was used to analyze the RA T cell repertoire. RESULTS: Of 5 TCR V beta gene products studied, only V beta 17-positive T cells were increased in peripheral blood and synovial fluid (SF) from RA patients, compared with controls (P < 0.01 and P = 0.0006, respectively). Thirty-one percent of the 49 RA SF samples and none of the 19 non-RA SF samples contained > 10% V beta 17-positive T cells. Activated (Tac-positive) T cells were enriched among V beta 17-positive synovial T cells. CONCLUSION: The selective increase of V beta 17-positive T cells suggests a role for those T cells in the pathogenesis of RA.
Authors: A A Vandenbark; E Morgan; R Bartholomew; D Bourdette; R Whitham; D Carlo; D Gold; G Hashim; H Offner Journal: Neurochem Res Date: 2001-06 Impact factor: 3.996
Authors: E Hodges; J Dasmahapatra; J L Smith; C T Quin; S Lanham; M T Krishna; S T Holgate; A J Frew Journal: Clin Exp Immunol Date: 1998-06 Impact factor: 4.330
Authors: Jorge Monserrat; Cristina Bohórquez; Ana María Gómez Lahoz; Atusa Movasat; Ana Pérez; Lucía Ruíz; David Díaz; Luis Chara; Ana Isabel Sánchez; Fernando Albarrán; Ignacio Sanz; Melchor Álvarez-Mon Journal: Cells Date: 2019-08-10 Impact factor: 6.600