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Literature DB >> 7945399

Why are there so many adrenoceptor subtypes?

G Milligan¹, P Svoboda, C M Brown.

Abstract

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Year: 1994 PMID： 7945399 DOI： 10.1016/0006-2952(94)90141-4

Source DB: PubMed Journal: Biochem Pharmacol ISSN： 0006-2952 Impact factor: 5.858

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13 in total

1. High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.

Authors: Vadim Cherezov; Daniel M Rosenbaum; Michael A Hanson; Søren G F Rasmussen; Foon Sun Thian; Tong Sun Kobilka; Hee-Jung Choi; Peter Kuhn; William I Weis; Brian K Kobilka; Raymond C Stevens
Journal: Science Date: 2007-10-25 Impact factor: 47.728

2. Pharmacological profile of intrathecal fadolmidine, a alpha2-adrenoceptor agonist, in rodent models.

Authors: Tiina Leino; Timo Viitamaa; Antti Haapalinna; Jyrki Lehtimäki; Raimo Virtanen
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2009-10-14 Impact factor: 3.000

3. A constitutively active mutant of the alpha 1B-adrenergic receptor can cause greater agonist-dependent down-regulation of the G-proteins G9 alpha and G11 alpha than the wild-type receptor.

Authors: T W Lee; A Wise; S Cotecchia; G Milligan
Journal: Biochem J Date: 1996-11-15 Impact factor: 3.857

4. β₂-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway.

Authors: Monica Galaz-Montoya; Sara J Wright; Gustavo J Rodriguez; Olivier Lichtarge; Theodore G Wensel
Journal: J Biol Chem Date: 2017-04-25 Impact factor: 5.157

5. Dopamine, norepinephrine and serotonin transporter gene deletions differentially alter cocaine-induced taste aversion.

Authors: Jermaine D Jones; F Scott Hall; George R Uhl; Anthony L Riley
Journal: Pharmacol Biochem Behav Date: 2009-12-04 Impact factor: 3.533

10. Computational study on the different ligands induced conformation change of β2 adrenergic receptor-Gs protein complex.

Authors: Qifeng Bai; Yang Zhang; Yihe Ban; Huanxiang Liu; Xiaojun Yao
Journal: PLoS One Date: 2013-07-29 Impact factor: 3.240

Why are there so many adrenoceptor subtypes?

1. High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.

2. Pharmacological profile of intrathecal fadolmidine, a alpha2-adrenoceptor agonist, in rodent models.

3. A constitutively active mutant of the alpha 1B-adrenergic receptor can cause greater agonist-dependent down-regulation of the G-proteins G9 alpha and G11 alpha than the wild-type receptor.

4. β₂-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway.

5. Dopamine, norepinephrine and serotonin transporter gene deletions differentially alter cocaine-induced taste aversion.

6. Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor.

Review 7. Atomic force microscopy: a multifaceted tool to study membrane proteins and their interactions with ligands.

8. A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor.

9. Structure-based discovery of beta2-adrenergic receptor ligands.

10. Computational study on the different ligands induced conformation change of β2 adrenergic receptor-Gs protein complex.