Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Bcl-2 overexpression abolishes early calcium waving preceding apoptosis in NIH-3T3 murine fibroblasts.

Literature DB >> 7945396

Bcl-2 overexpression abolishes early calcium waving preceding apoptosis in NIH-3T3 murine fibroblasts.

L Magnelli¹, M Cinelli, A Turchetti, V P Chiarugi.

Abstract

Overexpression of the apoptosis protection gene bcl-2 abolished the earliest response to serum withdrawal in NIH-3T3 murine fibroblasts, i.e., the abrupt cytoplasmic free calcium drop. This phenomenon, also observed in a myeloid cell line, led us to propose this ionic waving as an early apoptotic signal. Its abolition by bcl-2 overexpression suggests that this gene plays a role also on early events "priming" apoptosis.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1994 PMID： 7945396 DOI： 10.1006/bbrc.1994.2429

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

Keyword Cloud
Cited

15 in total

1. The mitophagy receptor Bcl-2-like protein 13 stimulates adipogenesis by regulating mitochondrial oxidative phosphorylation and apoptosis in mice.

Authors: Makoto Fujiwara; Li Tian; Phuong T Le; Victoria E DeMambro; Kathleen A Becker; Clifford J Rosen; Anyonya R Guntur
Journal: J Biol Chem Date: 2019-07-02 Impact factor: 5.157

Review 2. Bcl-2 proteins and calcium signaling: complexity beneath the surface.

Authors: T Vervliet; J B Parys; G Bultynck
Journal: Oncogene Date: 2016-03-14 Impact factor: 9.867

3. Protein kinase C δ (PKCδ) splice variants modulate apoptosis pathway in 3T3L1 cells during adipogenesis: identification of PKCδII inhibitor.

Authors: Rekha Patel; André Apostolatos; Gay Carter; Joanne Ajmo; Meghanath Gali; Denise R Cooper; Min You; Kirpal S Bisht; Niketa A Patel
Journal: J Biol Chem Date: 2013-07-31 Impact factor: 5.157

4. Bcl-2 and Bcl-X(L) block thapsigargin-induced nitric oxide generation, c-Jun NH(2)-terminal kinase activity, and apoptosis.

Authors: R K Srivastava; S J Sollott; L Khan; R Hansford; E G Lakatta; D L Longo
Journal: Mol Cell Biol Date: 1999-08 Impact factor: 4.272

Bcl-2 overexpression abolishes early calcium waving preceding apoptosis in NIH-3T3 murine fibroblasts.

1. The mitophagy receptor Bcl-2-like protein 13 stimulates adipogenesis by regulating mitochondrial oxidative phosphorylation and apoptosis in mice.

Review 2. Bcl-2 proteins and calcium signaling: complexity beneath the surface.

3. Protein kinase C δ (PKCδ) splice variants modulate apoptosis pathway in 3T3L1 cells during adipogenesis: identification of PKCδII inhibitor.

4. Bcl-2 and Bcl-X(L) block thapsigargin-induced nitric oxide generation, c-Jun NH(2)-terminal kinase activity, and apoptosis.

5. TRPC1 protects human SH-SY5Y cells against salsolinol-induced cytotoxicity by inhibiting apoptosis.

Review 6. Apoptosis and autophagy: decoding calcium signals that mediate life or death.

7. Odontoblast-targeted Bcl-2 overexpression impairs dentin formation.

Review 8. Bcl-2 interaction with the inositol 1,4,5-trisphosphate receptor: role in Ca(2+) signaling and disease.

9. Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stress.

10. TRPC1-mediated inhibition of 1-methyl-4-phenylpyridinium ion neurotoxicity in human SH-SY5Y neuroblastoma cells.