Literature DB >> 7945384

Molecular cloning and characterization of a cDNA for bovine phospholipase C-alpha: proposal of redesignation of phospholipase C-alpha.

N Hirano1, F Shibasaki, H Kato, R Sakai, T Tanaka, J Nishida, Y Yazaki, T Takenawa, H Hirai.   

Abstract

We have isolated bovine phospholipase C (PLC)-alpha cDNA from bovine thymus. Sequence analysis showed that PLC-alpha is highly conserved among rat, mouse, and calf and that it has two Trp-Cys-Gly-His-Cys-Lys motifs completely conserved in the mammals. Southern blot analysis revealed that bovine PLC-alpha is derived from a single gene. When PLC-alpha cDNA was stably transfected in NIH3T3 cells, there was no increase in PLC activity. PLC-alpha is supposed to be a member not of PLC superfamily but of Trp-Cys-Gly-His-Cys-Lys motif-containing proteins consisting of protein disulfide isomerase, P5, ERp72, and thioredoxin. PLC-alpha should be redesignated ERp57 (ER-resided p57).

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Year:  1994        PMID： 7945384     DOI： 10.1006/bbrc.1994.2469

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

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Authors:  R D Shortridge; R R McKay
Journal:  Invert Neurosci       Date:  1995-12

Review 2.  Role of N-oligosaccharide endoplasmic reticulum processing reactions in glycoprotein folding and degradation.

Authors:  A J Parodi
Journal:  Biochem J       Date:  2000-05-15       Impact factor: 3.857

3.  ER-60, a chaperone with thiol-dependent reductase activity involved in MHC class I assembly.

Authors:  J A Lindquist; O N Jensen; M Mann; G J Hämmerling
Journal:  EMBO J       Date:  1998-04-15       Impact factor: 11.598

4.  Ribozyme knockdown functionally links a 1,25(OH)2D3 membrane binding protein (1,25D3-MARRS) and phosphate uptake in intestinal cells.

Authors:  I Nemere; M C Farach-Carson; B Rohe; T M Sterling; A W Norman; B D Boyan; S E Safford
Journal:  Proc Natl Acad Sci U S A       Date:  2004-04-29       Impact factor: 11.205

5.  The platelet-surface thiol isomerase enzyme ERp57 modulates platelet function.

Authors:  L-M Holbrook; P Sasikumar; R G Stanley; A D Simmonds; A B Bicknell; J M Gibbins
Journal:  J Thromb Haemost       Date:  2012-02       Impact factor: 5.824

6.  Solution structure of multi-domain protein ER-60 studied by aggregation-free SAXS and coarse-grained-MD simulation.

Authors:  Aya Okuda; Masahiro Shimizu; Ken Morishima; Rintaro Inoue; Nobuhiro Sato; Reiko Urade; Masaaki Sugiyama
Journal:  Sci Rep       Date:  2021-03-11       Impact factor: 4.379
  6 in total

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