Literature DB >> 7945289

cDNA cloning and expression of bovine endothelin converting enzyme.

T Ikura1, T Sawamura, T Shiraki, H Hosokawa, T Kido, H Hoshikawa, K Shimada, K Tanzawa, S Kobayashi, S Miwa.   

Abstract

We have cloned cDNA encoding bovine endothelin converting enzyme (ECE). The predicted amino acid sequence of bovine ECE consisted of 758 amino acid residues. Northern blot analysis revealed that ECE mRNA was abundantly expressed in lung. Co-expression of the cloned cDNA of bovine ECE with human preproET-1 cDNA in CHO-K1 cells resulted in the production of mature ET-1 and this production was inhibited by phosphoramidon.

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Year:  1994        PMID： 7945289     DOI： 10.1006/bbrc.1994.2343

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  8 in total

1.  Histochemical distribution of endothelin-converting enzyme subtypes in Podarcis sicula (Squamata, Lacertidae) tissues.

Authors:  Salvatore Valiante; Marina Prisco; Maria De Falco; Francesca Virgilio; Rosaria Sciarrillo; Piero Andreuccetti; Vincenza Laforgia; Lorenzo Varano
Journal:  J Anat       Date:  2005-10       Impact factor: 2.610

2.  Linkage mapping of the endothelin-converting enzyme gene (Ednce) to rat chromosome 5.

Authors:  A Y Deng; J P Rapp
Journal:  Mamm Genome       Date:  1995-10       Impact factor: 2.957

Review 3.  The endothelin system and endothelin-converting enzyme in the brain: molecular and cellular studies.

Authors:  K Barnes; A J Turner
Journal:  Neurochem Res       Date:  1997-08       Impact factor: 3.996

4.  Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations.

Authors:  A Schweizer; O Valdenaire; P Nelböck; U Deuschle; J B Dumas Milne Edwards; J G Stumpf; B M Löffler
Journal:  Biochem J       Date:  1997-12-15       Impact factor: 3.857

5.  Phosphoramidon inhibition of the in vivo conversion of big endothelin-1 to endothelin-1 in the human forearm.

Authors:  C Plumpton; W G Haynes; D J Webb; A P Davenport
Journal:  Br J Pharmacol       Date:  1995-09       Impact factor: 8.739

Review 6.  The endothelin system as a therapeutic target in cardiovascular disease: great expectations or bleak house?

Authors:  N S Kirkby; P W F Hadoke; A J Bagnall; D J Webb
Journal:  Br J Pharmacol       Date:  2007-10-29       Impact factor: 8.739

7.  Identification of endothelin 1 and big endothelin 1 in secretory vesicles isolated from bovine aortic endothelial cells.

Authors:  V J Harrison; K Barnes; A J Turner; E Wood; R Corder; J R Vane
Journal:  Proc Natl Acad Sci U S A       Date:  1995-07-03       Impact factor: 11.205

8.  Localization of rat endothelin-converting enzyme to vascular endothelial cells and some secretory cells.

Authors:  M Takahashi; K Fukuda; K Shimada; K Barnes; A J Turner; M Ikeda; H Koike; Y Yamamoto; K Tanzawa
Journal:  Biochem J       Date:  1995-10-15       Impact factor: 3.857
  8 in total

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