Literature DB >> 7944643

Increased urinary nitrate excretion in rats with adjuvant arthritis.

D O Stichtenoth1, F M Gutzki, D Tsikas, N Selve, S M Bode-Böger, R H Böger, J C Frölich.   

Abstract

OBJECTIVES: In rats with adjuvant arthritis measurements were taken of the urinary excretion of nitrate, reflecting endogenous nitric oxide (NO) formation, and cyclic guanosine monophosphate (cGMP).
METHODS: Urinary nitrate was determined by gas chromatography, cGMP by radioimmunoassay.
RESULTS: A significant (p < 0.001), more than three fold increase of urinary nitrate excretion was found in rats 20 days after induction of adjuvant arthritis compared with non-arthritic rats. There was no significant difference in urinary cGMP excretion between arthritic rats and control animals.
CONCLUSION: The data suggest that the dramatic increase of urinary nitrate excretion is due to increase of NO synthesis by the inducible form of NO synthase.

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Year:  1994        PMID： 7944643      PMCID： PMC1005398          DOI： 10.1136/ard.53.8.547

Source DB:  PubMed          Journal:  Ann Rheum Dis        ISSN： 0003-4967            Impact factor:   19.103


  15 in total

1.  Modulation of nitrogen oxide synthesis in vivo: NG-monomethyl-L-arginine inhibits endotoxin-induced nitrate/nitrate biosynthesis while promoting hepatic damage.

Authors:  T R Billiar; R D Curran; B G Harbrecht; D J Stuehr; A J Demetris; R L Simmons
Journal:  J Leukoc Biol       Date:  1990-12       Impact factor: 4.962

Review 2.  The 1991 Ulf von Euler Lecture. The L-arginine: nitric oxide pathway.

Authors:  S Moncada
Journal:  Acta Physiol Scand       Date:  1992-07

3.  Dependence of the metabolism of nitric oxide (NO) in healthy human whole blood on the oxygenation of its red cell haemoglobin.

Authors:  A Wennmalm; G Benthin; A S Petersson
Journal:  Br J Pharmacol       Date:  1992-07       Impact factor: 8.739

Review 4.  The L-arginine-nitric oxide pathway.

Authors:  S Moncada; A Higgs
Journal:  N Engl J Med       Date:  1993-12-30       Impact factor: 91.245

5.  Determination of endothelium-derived nitrite/nitrate by gas chromatography/tandem mass spectrometry using (15N)NaNO2 as internal standard.

Authors:  F M Gutzki; D Tsikas; U Alheid; J C Frölich
Journal:  Biol Mass Spectrom       Date:  1992-02

6.  Endothelial cyclic GMP and cyclic AMP do not regulate the release of endothelium-derived relaxing factor/nitric oxide from bovine aortic endothelial cells.

Authors:  M Kuhn; A Otten; J C Frölich; U Förstermann
Journal:  J Pharmacol Exp Ther       Date:  1991-02       Impact factor: 4.030

7.  Increases in NO2-/NO3- excretion in the urine as an indicator of the release of endothelium-derived relaxing factor during elevation of blood pressure.

Authors:  H Suzuki; H Ikenaga; K Hishikawa; T Nakaki; R Kato; T Saruta
Journal:  Clin Sci (Lond)       Date:  1992-06       Impact factor: 6.124

8.  Nitric oxide production by monocytes in alcoholic liver disease.

Authors:  N C Hunt; R D Goldin
Journal:  J Hepatol       Date:  1992-03       Impact factor: 25.083

9.  Use of Freund's adjuvant arthritis test in anti-flammatory drug screening in the rat: value of animal selection and preparation at the breeding center.

Authors:  C Gouret; G Mocquet; G Raynaud
Journal:  Lab Anim Sci       Date:  1976-04

10.  Urinary nitrate excretion in relation to murine macrophage activation. Influence of dietary L-arginine and oral NG-monomethyl-L-arginine.

Authors:  D L Granger; J B Hibbs; L M Broadnax
Journal:  J Immunol       Date:  1991-02-15       Impact factor: 5.422
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  2 in total

1.  Suppression of adjuvant arthritis and synovial macrophage inducible nitric oxide by N-iminoethyl-L-ornithine, a nitric oxide synthase inhibitor.

Authors:  L L Santos; E F Morand; Y Yang; P Hutchinson; S R Holdsworth
Journal:  Inflammation       Date:  1997-06       Impact factor: 4.092

2.  Urinary nitrate excretion is increased in patients with rheumatoid arthritis and reduced by prednisolone.

Authors:  D O Stichtenoth; J Fauler; H Zeidler; J C Frölich
Journal:  Ann Rheum Dis       Date:  1995-10       Impact factor: 19.103
  2 in total

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