OBJECTIVE: To identify colorectal cancers occurring after colonoscopic screening in patients at risk for Lynch syndrome. METHODS: All cancers in Lynch syndrome families on file at the Creighton University Hereditary Cancer Institute were reviewed for history of prior colonoscopy. RESULTS: Of 225 individuals with 313 colon cancers, six patients from different families had colon cancers arising within 4 1/2 yr of colonoscopic surveillance. Another 17 patients had metachronous colon cancers within 5 yr of resection of their first colon cancer. CONCLUSION: Of 225 colorectal cancer patients from Lynch syndrome families, 10.2% of patients had colorectal cancer within 5 yr of colonoscopy or colon resection. In Lynch syndrome, the potential for interval neoplasms and the malignant potential of missed diminutive adenomas may differ from cases in the general population.
OBJECTIVE: To identify colorectal cancers occurring after colonoscopic screening in patients at risk for Lynch syndrome. METHODS: All cancers in Lynch syndrome families on file at the Creighton University Hereditary Cancer Institute were reviewed for history of prior colonoscopy. RESULTS: Of 225 individuals with 313 colon cancers, six patients from different families had colon cancers arising within 4 1/2 yr of colonoscopic surveillance. Another 17 patients had metachronous colon cancers within 5 yr of resection of their first colon cancer. CONCLUSION: Of 225 colorectal cancerpatients from Lynch syndrome families, 10.2% of patients had colorectal cancer within 5 yr of colonoscopy or colon resection. In Lynch syndrome, the potential for interval neoplasms and the malignant potential of missed diminutive adenomas may differ from cases in the general population.
Authors: Jurjen J Boonstra; Wouter H de Vos Tot Nederveen Cappel; Alexandra M J Langers; Hedwig van der Sluis; James H Hardwick; Hans F A Vasen Journal: Fam Cancer Date: 2017-04 Impact factor: 2.375
Authors: Henry T Lynch; Carrie L Snyder; Trudy G Shaw; Christopher D Heinen; Megan P Hitchins Journal: Nat Rev Cancer Date: 2015-02-12 Impact factor: 60.716
Authors: Robert W Haile; Henry T Lynch; Megan P Hitchins; Ingrid P Vogelaar; Kevin Brennan; Sigurdis Haraldsdottir; Nianmin Zhou; Brock Martin; Rocio Alvarez; Xiaopu Yuan; Sungjin Kim; Maha Guindi; Andrew E Hendifar; Matthew F Kalady; Jennifer DeVecchio; James M Church; Albert de la Chapelle; Heather Hampel; Rachel Pearlman; Maria Christensen; Carrie Snyder; Stephen J Lanspa Journal: BMJ Open Gastroenterol Date: 2019-05-28
Authors: Hans F A Vasen; Mary E Velthuizen; Jan H Kleibeuker; Fred H Menko; Fokke M Nagengast; Annemieke Cats; Andrea E van der Meulen-de Jong; Martijn H Breuning; Anne J Roukema; Inge van Leeuwen-Cornelisse; Wouter H de Vos Tot Nederveen Cappel; Juul T Wijnen Journal: Fam Cancer Date: 2016-07 Impact factor: 2.375