Literature DB >> 7940679

Mechanisms of mRNA degradation in eukaryotes.

C J Decker1, R Parker.   

Abstract

Recent experiments have identified distinct mechanisms of eukaryotic RNA turnover. In one mechanism, deadenylation triggers decapping, exposing the messenger RNA to 5' to 3' degradation. This pathway may act at different rates on the majority of messenger RNAs. There are also degradation mechanisms, such as endonucleolytic cleavage, limited to messenger RNAs containing specific sequence elements.

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Year:  1994        PMID： 7940679     DOI： 10.1016/0968-0004(94)90073-6

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  81 in total

1.  UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs.

Authors:  G Pesole; S Liuni; G Grillo; F Licciulli; A Larizza; W Makalowski; C Saccone
Journal:  Nucleic Acids Res       Date:  2000-01-01       Impact factor: 16.971

2.  5' cloverleaf in poliovirus RNA is a cis-acting replication element required for negative-strand synthesis.

Authors:  D J Barton; B J O'Donnell; J B Flanegan
Journal:  EMBO J       Date:  2001-03-15       Impact factor: 11.598

3.  Identification of an erythroid-enriched endoribonuclease activity involved in specific mRNA cleavage.

Authors:  Z Wang; M Kiledjian
Journal:  EMBO J       Date:  2000-01-17       Impact factor: 11.598

4.  UTRdb and UTRsite: specialized databases of sequences and functional elements of 5' and 3' untranslated regions of eukaryotic mRNAs. Update 2002.

Authors:  Graziano Pesole; Sabino Liuni; Giorgio Grillo; Flavio Licciulli; Flavio Mignone; Carmela Gissi; Cecilia Saccone
Journal:  Nucleic Acids Res       Date:  2002-01-01       Impact factor: 16.971

5.  Poly(rC) binding proteins mediate poliovirus mRNA stability.

Authors:  K E Murray; A W Roberts; D J Barton
Journal:  RNA       Date:  2001-08       Impact factor: 4.942

6.  The poly(A)-binding protein and an mRNA stability protein jointly regulate an endoribonuclease activity.

Authors:  Z Wang; M Kiledjian
Journal:  Mol Cell Biol       Date:  2000-09       Impact factor: 4.272

7.  The major yeast poly(A)-binding protein is associated with cleavage factor IA and functions in premessenger RNA 3'-end formation.

Authors:  L Minvielle-Sebastia; P J Preker; T Wiederkehr; Y Strahm; W Keller
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-22       Impact factor: 11.205

8.  mRNA decapping in yeast requires dissociation of the cap binding protein, eukaryotic translation initiation factor 4E.

Authors:  D C Schwartz; R Parker
Journal:  Mol Cell Biol       Date:  2000-11       Impact factor: 4.272

9.  Selective degradation of early-response-gene mRNAs: functional analyses of sequence features of the AU-rich elements.

Authors:  C Y Chen; A B Shyu
Journal:  Mol Cell Biol       Date:  1994-12       Impact factor: 4.272

10.  Capped mRNA degradation intermediates accumulate in the yeast spb8-2 mutant.

Authors:  R Boeck; B Lapeyre; C E Brown; A B Sachs
Journal:  Mol Cell Biol       Date:  1998-09       Impact factor: 4.272
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