| Literature DB >> 7939632 |
H Fu1, K Xia, D C Pallas, C Cui, K Conroy, R P Narsimhan, H Mamon, R J Collier, T M Roberts.
Abstract
Members of a family of highly conserved proteins, termed 14-3-3 proteins, were found by several experimental approaches to associate with Raf-1, a central component of a key signal transduction pathway. Optimal complex formation required the amino-terminal regulatory domain of Raf-1. The association of 14-3-3 proteins and Raf-1 was not substantially affected by the activation state of Raf.Entities:
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Year: 1994 PMID: 7939632 DOI: 10.1126/science.7939632
Source DB: PubMed Journal: Science ISSN: 0036-8075 Impact factor: 47.728