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Literature DB >> 7937940

Linker histones H1 and H5 prevent the mobility of positioned nucleosomes.

S Pennings¹, G Meersseman, E M Bradbury.

Abstract

We have previously identified a generally occurring short-range mobility of nucleosome cores on DNA in relatively low ionic strength conditions. Here we report that this mobility of histone octamers positioned on constructs of 5S rDNA is suppressed by the binding of histone H1 or H5 to the nucleosome. Histone H5 is the more potent inhibitor of nucleosome mobility, in accordance with its higher affinity for chromatin. We propose that this reversible restraint on chromatin dynamics may play a role in local regulation of processes that require access to the DNA.

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Year: 1994 PMID： 7937940 PMCID： PMC45002 DOI： 10.1073/pnas.91.22.10275

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

40 in total

Review 1. What happens to nucleosomes during transcription?

Authors: K E van Holde; D E Lohr; C Robert
Journal: J Biol Chem Date: 1992-02-15 Impact factor: 5.157

2. Chromatin reconstitution on small DNA rings. IV. DNA supercoiling and nucleosome sequence preference.

Authors: I Duband-Goulet; V Carot; A V Ulyanov; S Douc-Rasy; A Prunell
Journal: J Mol Biol Date: 1992-04-20 Impact factor: 5.469

3. Effect of glycerol on the separation of nucleosomes and bent DNA in low ionic strength polyacrylamide gel electrophoresis.

Authors: S Pennings; G Meersseman; E M Bradbury
Journal: Nucleic Acids Res Date: 1992-12-25 Impact factor: 16.971

Review 4. Structural changes in nucleosomes during transcription: strip, split or flip?

Authors: F Thoma
Journal: Trends Genet Date: 1991-06 Impact factor: 11.639

5. Role of nucleosomal cores and histone H1 in regulation of transcription by RNA polymerase II.

Authors: P J Laybourn; J T Kadonaga
Journal: Science Date: 1991-10-11 Impact factor: 47.728

6. A light microscope study of linker histone distribution in rat metaphase chromosomes and interphase nuclei.

Authors: J W Breneman; P Yau; R L Teplitz; E M Bradbury
Journal: Exp Cell Res Date: 1993-05 Impact factor: 3.905

Review 7. Multiple functions of nucleosomes and regulatory factors in transcription.

Authors: J L Workman; A R Buchman
Journal: Trends Biochem Sci Date: 1993-03 Impact factor: 13.807

Review 8. Reversible histone modifications and the chromosome cell cycle.

Authors: E M Bradbury
Journal: Bioessays Date: 1992-01 Impact factor: 4.345

9. Nucleosome spacing is compressed in active chromatin domains of chick erythroid cells.

Authors: B Villeponteau; J Brawley; H G Martinson
Journal: Biochemistry Date: 1992-02-11 Impact factor: 3.162

10. Mobile nucleosomes--a general behavior.

Authors: G Meersseman; S Pennings; E M Bradbury
Journal: EMBO J Date: 1992-08 Impact factor: 11.598

57 in total

1. The H3-H4 N-terminal tail domains are the primary mediators of transcription factor IIIA access to 5S DNA within a nucleosome.

Authors: J M Vitolo; C Thiriet; J J Hayes
Journal: Mol Cell Biol Date: 2000-03 Impact factor: 4.272

Linker histones H1 and H5 prevent the mobility of positioned nucleosomes.

Review 1. What happens to nucleosomes during transcription?

2. Chromatin reconstitution on small DNA rings. IV. DNA supercoiling and nucleosome sequence preference.

3. Effect of glycerol on the separation of nucleosomes and bent DNA in low ionic strength polyacrylamide gel electrophoresis.

Review 4. Structural changes in nucleosomes during transcription: strip, split or flip?

5. Role of nucleosomal cores and histone H1 in regulation of transcription by RNA polymerase II.

6. A light microscope study of linker histone distribution in rat metaphase chromosomes and interphase nuclei.

Review 7. Multiple functions of nucleosomes and regulatory factors in transcription.

Review 8. Reversible histone modifications and the chromosome cell cycle.

9. Nucleosome spacing is compressed in active chromatin domains of chick erythroid cells.

10. Mobile nucleosomes--a general behavior.

1. The H3-H4 N-terminal tail domains are the primary mediators of transcription factor IIIA access to 5S DNA within a nucleosome.

Review 2. Nucleosome sliding: facts and fiction.

3. Computational study of remodeling in a nucleosomal array.

4. The preferential binding of histone H1 to DNA scaffold-associated regions is determined by its C-terminal domain.

5. The histone fold subunits of Drosophila CHRAC facilitate nucleosome sliding through dynamic DNA interactions.

Review 6. Role of linker histone in chromatin structure and function: H1 stoichiometry and nucleosome repeat length.

7. The nucleosome: a transparent, slippery, sticky and yet stable DNA-protein complex.

8. Nucleosome binding by the polymerase I transactivator upstream binding factor displaces linker histone H1.

9. ACF catalyses chromatosome movements in chromatin fibres.

10. HMG-D and histone H1 alter the local accessibility of nucleosomal DNA.