Literature DB >> 7937532

Distribution of brush-border membrane peptidases along the rat intestine.

J P Bai1.   

Abstract

The longitudinal distribution of brush-border endopeptidase-24.11, endopeptidase-2, aminopeptidase W, angiotensin-converting enzyme (ACE), dipeptidyl peptidase IV (DPP IV), carboxypeptidase P, and aminopeptidase P in the rat intestine was determined. The jejunum has the highest activities of endopeptidase-24.11 and ACE while the ileum has the highest activities of aminopeptidase W and carboxypeptidase P, and the jejunoileal junction has the highest activity of aminopeptidase P. The jejunum and ileum have similar activities of DPP IV. The profiles of differential hydrolysis of neurotensin and acetylneurotensin (8-13) along the intestine agree with distribution of endopeptidase-24.11 and ACE, suggesting that amino acid sequences of peptides and the substrate specificity of enzymes will determine site-dependent hydrolysis. There is substantial similarity in the intestinal distribution of peptidases in the human, rat, and rabbit.

Entities:  

Mesh：

Substances：

Year:  1994        PMID： 7937532     DOI： 10.1023/a:1018946228432

Source DB:  PubMed          Journal:  Pharm Res        ISSN： 0724-8741            Impact factor:   4.200


  20 in total

1.  Role of rat intestinal brush-border membrane angiotensin-converting enzyme in dietary protein digestion.

Authors:  M Yoshioka; R H Erickson; J F Woodley; R Gulli; D Guan; Y S Kim
Journal:  Am J Physiol       Date:  1987-12

2.  The effect of site of administration in the gastrointestinal tract on the absorption of insulin from nanocapsules in diabetic rats.

Authors:  C Michel; M Aprahamian; L Defontaine; P Couvreur; C Damgé
Journal:  J Pharm Pharmacol       Date:  1991-01       Impact factor: 3.765

3.  New chromogenic substrates for X-prolyl dipeptidyl-aminopeptidase.

Authors:  T Nagatsu; M Hino; H Fuyamada; T Hayakawa; S Sakakibara
Journal:  Anal Biochem       Date:  1976-08       Impact factor: 3.365

4.  Dipeptidylaminopeptidase and carboxypeptidase activities of the brush border of rabbit small intestine.

Authors:  S Auricchio; L Greco; B de Vizia; V Buonocore
Journal:  Gastroenterology       Date:  1978-12       Impact factor: 22.682

5.  The metabolism of neuropeptides. Hydrolysis of peptides by the phosphoramidon-insensitive rat kidney enzyme 'endopeptidase-2' and by rat microvillar membranes.

Authors:  S L Stephenson; A J Kenny
Journal:  Biochem J       Date:  1988-10-01       Impact factor: 3.857

6.  The distribution of brush border peptidases along the small intestine of the adult human.

Authors:  E E Sterchi
Journal:  Pediatr Res       Date:  1981-05       Impact factor: 3.756

7.  The absorption of insulin from various regions of the rat intestine.

Authors:  M Kidron; H Bar-On; E M Berry; E Ziv
Journal:  Life Sci       Date:  1982-12-20       Impact factor: 5.037

8.  Immunoelectrophoretic studies on human small intestinal brush border proteins--the longitudinal distribution of peptidases and disaccharidases.

Authors:  H Skovbjerg
Journal:  Clin Chim Acta       Date:  1981-05-05       Impact factor: 3.786

9.  Distribution of brush-border membrane peptidases along the rabbit intestine: implication for oral delivery of peptide drugs.

Authors:  J P Bai
Journal:  Life Sci       Date:  1993       Impact factor: 5.037

10.  A fluorimetric assay for aminopeptidase W.

Authors:  M C Jackson; Y Choudry; A Bourne; J F Woodley; A J Kenny
Journal:  Biochem J       Date:  1988-07-01       Impact factor: 3.857
View more
  7 in total

1.  Rat jejunal permeability and metabolism of mu-selective tetrapeptides in gastrointestinal fluids from humans and rats.

Authors:  E Krondahl; A Orzechowski; G Ekström; H Lennernäs
Journal:  Pharm Res       Date:  1997-12       Impact factor: 4.200

2.  Oral absorption of D-oligopeptides in rats via the paracellular route.

Authors:  Y L He; S Murby; L Gifford; A Collett; G Warhurst; K T Douglas; M Rowland; J Ayrton
Journal:  Pharm Res       Date:  1996-11       Impact factor: 4.200

3.  Expression of genes encoding for drug metabolising cytochrome P450 enzymes and P-glycoprotein in the rat small intestine; comparison to the liver.

Authors:  Monica Lindell; Matti Lang; Hans Lennernäs
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2003 Jan-Mar       Impact factor: 2.441

Review 4.  Heteromeric Solute Carriers: Function, Structure, Pathology and Pharmacology.

Authors:  Stephen J Fairweather; Nishank Shah; Stefan Brӧer
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

5.  Epithelial transport of immunogenic and toxic gliadin peptides in vitro.

Authors:  Christian Zimmermann; Silvia Rudloff; Günter Lochnit; Sevgi Arampatzi; Wolfgang Maison; Klaus-Peter Zimmer
Journal:  PLoS One       Date:  2014-11-21       Impact factor: 3.240

Review 6.  Review article: the pathophysiological roles of the renin-angiotensin system in the gastrointestinal tract.

Authors:  M Garg; P W Angus; L M Burrell; C Herath; P R Gibson; J S Lubel
Journal:  Aliment Pharmacol Ther       Date:  2012-01-05       Impact factor: 8.171

7.  Intestinal Inflammation Modulates the Expression of ACE2 and TMPRSS2 and Potentially Overlaps With the Pathogenesis of SARS-CoV-2-related Disease.

Authors:  Mayte Suárez-Fariñas; Minami Tokuyama; Gabrielle Wei; Ruiqi Huang; Alexandra Livanos; Divya Jha; Anais Levescot; Haritz Irizar; Roman Kosoy; Sascha Cording; Wenhui Wang; Bojan Losic; Ryan Ungaro; Antonio Di'Narzo; Gustavo Martinez-Delgado; Maria Suprun; Michael J Corley; Aleksandar Stojmirovic; Sander M Houten; Lauren Peters; Mark Curran; Carrie Brodmerkel; Jacqueline Perrigoue; Joshua R Friedman; Ke Hao; Eric E Schadt; Jun Zhu; Huaibin M Ko; Judy Cho; Marla C Dubinsky; Bruce E Sands; Lishomwa Ndhlovu; Nadine Cerf-Bensusan; Andrew Kasarskis; Jean Frederic Colombel; Noam Harpaz; Carmen Argmann; Saurabh Mehandru
Journal:  Gastroenterology       Date:  2020-09-25       Impact factor: 22.682
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.