Literature DB >> 793750

Features of the immune response to DNA in mice II. Participation of B and T cells.

G J Fournié, P H Lambert, A D Bankhurst, P A Miescher.   

Abstract

The respective roles of thymus-derived and bone marrow-derived lymphocytes in the immune response to DNA was investigated in mice reconstituted with various cell populations using cell transfers. A helper effect of thymus-derived cells in the immune response to DNA was suggested by experiments performed in athymic nude BALB/c mice. Reconstitution experiments performed in low responder DBA/mice indicated that the immune response to DNA can be increased after transfer of bone marrow cells from high responder NZB mice, even in the presence of thymocytes from DBA/2 mice. In NZB X NZW mice, a major role of bone marrow cells, with a possible modulation by thymus-derived cells during aging, was observed in the spontaneous development of anti-DNA antibodies.

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Year:  1976        PMID： 793750      PMCID： PMC1540821     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  11 in total

1.  Spontaneous "autoimmune disease" in nude mice.

Authors:  H C Morse; A D Steinberg; P H Schur; N D Reed
Journal:  J Immunol       Date:  1974-08       Impact factor: 5.422

Review 2.  Mechanisms of tolerance and autoimmunity.

Authors:  A C Allison
Journal:  Ann Rheum Dis       Date:  1973-07       Impact factor: 19.103

3.  Age-decrease of cells sensitive to an autoantibody-specific for thymocytes and thymus-dependent lymphocytes in NZB mice.

Authors:  T Shirai; T Yoshiki; R C Mellors
Journal:  Clin Exp Immunol       Date:  1972-12       Impact factor: 4.330

4.  Autoimmune phenomena and renal disease in mice. Role of thymectomy, aging, and involution of immunologic capacity.

Authors:  P O Teague; E J Yunis; G Rodey; A J Fish; O Stutman; R A Good
Journal:  Lab Invest       Date:  1970-02       Impact factor: 5.662

5.  Deoxyribonucleic acid antibody: a method to detect its primary interaction with deoxyribonucleic acid.

Authors:  R T Wold; F E Young; E M Tan; R S Farr
Journal:  Science       Date:  1968-08-23       Impact factor: 47.728

6.  Nature and mode of action of antilymphocytic antiserum.

Authors:  R H Levey; P B Medawar
Journal:  Proc Natl Acad Sci U S A       Date:  1966-10       Impact factor: 11.205

7.  Loss with age in NZB-W mice of thymic suppressor cells in the graft-vs-host reaction.

Authors:  N L Gerber; J A Hardin; T M Chused; A D Steinberg
Journal:  J Immunol       Date:  1974-11       Impact factor: 5.422

8.  Natural thymocytotoxic autoantibody and reactive antigen in New Zealand black and other mice.

Authors:  T Shirai; R C Mellors
Journal:  Proc Natl Acad Sci U S A       Date:  1971-07       Impact factor: 11.205

9.  Release of DNA in circulating blood and induction of anti-DNA antibodies after injection of bacterial lipopolysaccharides.

Authors:  G J Fournié; P H Lambert; P A Meischer
Journal:  J Exp Med       Date:  1974-11-01       Impact factor: 14.307

10.  Termination of tolerance to human gamma globulin in mice by antigen and bacterial lipopolysaccharide (endotoxin).

Authors:  J M Chiller; W O Weigle
Journal:  J Exp Med       Date:  1973-03-01       Impact factor: 14.307
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  1 in total

1.  T cell abnormalities in NZB mice occur independently of autoantibody production.

Authors:  J D Taurog; E S Raveche; P A Smathers; L H Glimcher; D P Huston; C T Hansen; A D Steinberg
Journal:  J Exp Med       Date:  1981-02-01       Impact factor: 14.307
  1 in total

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