Literature DB >> 793669

Centrally induced hypotension and bradycardia after administration of alpha-methylnoradrenaline into the area of the nucleus tractus solitarii of the rat.

W De Jong, F P Nijkamp.   

Abstract

1 In anaesthetized rats, bilateral injections of alpha-methylnoradrenaline, noradrenaline or adrenaline into the area of the nucleus tractus solitarii (NTS) of the brain stem caused dose-dependent decreases of systemic arterial blood pressure and heart rate. The effects of alpha-methylnoradrenaline were most pronounced and lasted longest. 2 The cardiovascular effects of alpha-methylnoradrenaline appeared to be restricted to the medio-caudal part of the NTS. 3 Prior administration of the alpha-adrenoceptor blocking agent, phentolamine, reversed the fall in blood pressure and heart rate induced by alpha-methylnoradrenaline into an increase. 4 Systemic administration of atropine combined with vagotomy potentiated the inhibitory effects of alpha-methylnoradrenaline on the cardiovascular system.

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Year:  1976        PMID： 793669      PMCID： PMC1667478          DOI： 10.1111/j.1476-5381.1976.tb08628.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  18 in total

1.  EVIDENCE FOR THE EXISTENCE OF MONOAMINE NEURONS IN THE CENTRAL NERVOUS SYSTEM. IV. DISTRIBUTION OF MONOAMINE NERVE TERMINALS IN THE CENTRAL NERVOUS SYSTEM.

Authors:  K FUXE
Journal:  Acta Physiol Scand Suppl       Date:  1965

2.  Central inhibitory noradrenergic cardiovascular control.

Authors:  W de Jong; P Zandberg; B Bohus
Journal:  Prog Brain Res       Date:  1975       Impact factor: 2.453

3.  Central inhibitory effect of alpha-methyldopa on blood pressure, heart rate and body temperature of renal hypertensive rats.

Authors:  F P Nijkamp; J Ezer; W De Jong
Journal:  Eur J Pharmacol       Date:  1975-04       Impact factor: 4.432

4.  Role of noradrenaline and serotonin in the central control of blood pressure in normotensive and spontaneously hypertensive rats.

Authors:  W de Jong; F P Nijkamp; B Bohus
Journal:  Arch Int Pharmacodyn Ther       Date:  1975-02

5.  Central hypotensive effect of alpha-methyldopa.

Authors:  M Henning; P A van Zwieten
Journal:  J Pharm Pharmacol       Date:  1968-06       Impact factor: 3.765

6.  Central alpha- and beta-adrenoceptors modifying arterial blood pressure and heart rate in conscious cats.

Authors:  M D Day; A G Roach
Journal:  Br J Pharmacol       Date:  1974-07       Impact factor: 8.739

7.  Cardiovascular effects of sympathomimetic amines injected into the cerebral ventricles of rabbits.

Authors:  N Toda; Y Matsuda; K Shimamoto
Journal:  Int J Neuropharmacol       Date:  1969-09

8.  alpha-Methylnoradrenaline induced hypotension and bradycardia after administration into the area of the nucleus tractus solitarii.

Authors:  F P Nijkamp; W De Jong
Journal:  Eur J Pharmacol       Date:  1975 Jun-Jul       Impact factor: 4.432

9.  Studies on the hypotensive action of alpha-methyldopamine.

Authors:  L Finch; A Hersom; P Hicks
Journal:  Br J Pharmacol       Date:  1975-08       Impact factor: 8.739

Review 10.  Central sympathetic transmitters and hypertension.

Authors:  M Henning
Journal:  Clin Sci Mol Med Suppl       Date:  1975-06
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  14 in total

1.  Involvement of opiate system in the alpha 2-adrenergic depressor and bradycardiac effects evoked by microinjection of norepinephrine into the CNTS of rabbits.

Authors:  H Ding; J H Wu; K Yang
Journal:  J Tongji Med Univ       Date:  1987

Review 2.  Pharmacology of centrally acting hypotensive drugs.

Authors:  P A van Zwieten
Journal:  Br J Clin Pharmacol       Date:  1980       Impact factor: 4.335

3.  Evidence for a neuromodulatory role of GABA at the first synapse of the baroreceptor reflex pathway. Effects of GABA derivatives injected into the NTS.

Authors:  P Bousquet; J Feldman; R Bloch; J Schwartz
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1982-05       Impact factor: 3.000

4.  A method for injecting drugs into the nucleus tractus solitarii of conscious rats [proceedings].

Authors:  T L Berridge; G D Leach
Journal:  Br J Pharmacol       Date:  1978-11       Impact factor: 8.739

5.  Effect of prolonged clonidine treatment and its withdrawal on noradrenaline turnover in the cerebral cortex and medulla oblongata of the spontaneously hypertensive rat.

Authors:  J Atkinson; N Boillat; T Dennis; S Z Langer; B Scatton
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-07       Impact factor: 3.000

6.  Distribution and uptake of glycine, glutamate and gamma-aminobutyric acid in the vagal nuclei and eight other regions of the rat medulla oblongata.

Authors:  E R Siemers; M A Rea; D L Felten; M H Aprison
Journal:  Neurochem Res       Date:  1982-04       Impact factor: 3.996

7.  Pharmacological characterisation of the alpha-adrenoceptors responsible for a decrease of blood pressure in the nucleus tractus solitarii of the rat.

Authors:  T Kubo; Y Misu
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-09       Impact factor: 3.000

8.  Alpha-methyldopa induces a naltrexone-insensitive antinociception and hypomotility in rats.

Authors:  P L van Giersbergen; E van Duinkerken; C G Sweep; V M Wiegant; J M van Ree; W de Jong
Journal:  Br J Pharmacol       Date:  1990-03       Impact factor: 8.739

9.  Cardiovascular effects in rats of alpha 1 and alpha 2 adrenergic agents injected into the nucleus tractus solitarii.

Authors:  T Kubo; M Kihara; H Hata; Y Misu
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-03       Impact factor: 3.000

10.  Evidence that locus coeruleus is the site where clonidine and drugs acting at alpha 1- and alpha 2-adrenoceptors affect sleep and arousal mechanisms.

Authors:  G B De Sarro; C Ascioti; F Froio; V Libri; G Nisticò
Journal:  Br J Pharmacol       Date:  1987-04       Impact factor: 8.739
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