Human core temperature minimum can be modified by ambient thermal transients.

By using slow linear thermal transients (+/- 0.025 degree C/min) of reduced amplitude (+/- 3 degrees C around thermoneutrality), we were able to advance the minimum of human internal temperature (Ti) during nocturnal sleep. During experimental night the minimum of esophageal (Tes) and rectal (Tre) temperature were respectively advanced by 1.6 h (P < 0.01) and 2.6 h (P < 0.001) in comparison to reference night spent at thermoneutrality. It must be emphasized that the provoked advance of nocturnal Ti minimum was not accompanied by any change in sleep latency, efficiency, SWS and REM sleep percentages. The result shows that appropriate ambient temperature transient changes could be used to modify the course of human Ti one of the major biological rhythms usually considered as resistant to sleep-wake rhythm manipulation.