Literature DB >> 7935836

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function.

A Pause1, G J Belsham, A C Gingras, O Donzé, T A Lin, J C Lawrence, N Sonenberg.   

Abstract

The cloning is described of two related human complementary DNAs encoding polypeptides that interact specifically with the translation initiation factor eIF-4E, which binds to the messenger RNA 5'-cap structure. Interaction of these proteins with eIF-4E inhibits translation but treatment of cells with insulin causes one of them to become hyperphosphorylated and dissociate from eIF-4E, thereby relieving the translational inhibition. The action of this new regulator of protein synthesis is therefore modulated by insulin, which acts to stimulate the overall rate of translation and promote cell growth.

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Year:  1994        PMID： 7935836     DOI： 10.1038/371762a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  435 in total

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Authors:  J G Tjuvajev; A Joshi; J Callegari; L Lindsley; R Joshi; J Balatoni; R Finn; S M Larson; M Sadelain; R G Blasberg
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4.  Hierarchical phosphorylation of the translation inhibitor 4E-BP1.

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5.  Truncated initiation factor eIF4G lacking an eIF4E binding site can support capped mRNA translation.

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6.  The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure.

Authors:  Y V Svitkin; A Pause; A Haghighat; S Pyronnet; G Witherell; G J Belsham; N Sonenberg
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9.  The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k.

Authors:  S R von Manteuffel; P B Dennis; N Pullen; A C Gingras; N Sonenberg; G Thomas
Journal:  Mol Cell Biol       Date:  1997-09       Impact factor: 4.272

10.  Vesicular stomatitis virus infection alters the eIF4F translation initiation complex and causes dephosphorylation of the eIF4E binding protein 4E-BP1.

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