Literature DB >> 7935795

Activation of Raf-1 by 14-3-3 proteins.

W J Fantl1, A J Muslin, A Kikuchi, J A Martin, A M MacNicol, R W Gross, L T Williams.   

Abstract

The protein Raf-1, a key mediator of mitogenesis and differentiation, associates with p21ras (refs 1-3). However, the regulation of the serine/threonine kinase activity of Raf-1 is still not understood. Using the yeast two-hybrid system, we identified two structurally related proteins that interact with the aminoterminal region of Raf-1. These proteins, 14-3-3 zeta (PLA2) and 14-3-3 beta (HS1), are members of the 14-3-3 family of proteins. Expression of 14-3-3 proteins in Xenopus oocytes enhanced Raf-1 activity and promoted Raf-1-dependent oocyte maturation. A dominant negative mutant of Raf-1 blocked the effects of 14-3-3 protein.

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Year:  1994        PMID： 7935795     DOI： 10.1038/371612a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  85 in total

Review 1.  Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions.

Authors:  W Kolch
Journal:  Biochem J       Date:  2000-10-15       Impact factor: 3.857

Review 2.  Consummating signal transduction: the role of 14-3-3 proteins in the completion of signal-induced transitions in protein activity.

Authors:  Paul C Sehnke; Justin M DeLille; Robert J Ferl
Journal:  Plant Cell       Date:  2002       Impact factor: 11.277

3.  Structural view of a fungal toxin acting on a 14-3-3 regulatory complex.

Authors:  Martin Würtele; Christian Jelich-Ottmann; Alfred Wittinghofer; Claudia Oecking
Journal:  EMBO J       Date:  2003-03-03       Impact factor: 11.598

4.  The Arabidopsis 14-3-3 multigene family.

Authors:  K Wu; M F Rooney; R J Ferl
Journal:  Plant Physiol       Date:  1997-08       Impact factor: 8.340

5.  14-3-3 proteins block apoptosis and differentially regulate MAPK cascades.

Authors:  H Xing; S Zhang; C Weinheimer; A Kovacs; A J Muslin
Journal:  EMBO J       Date:  2000-02-01       Impact factor: 11.598

6.  14-3-3 antagonizes Ras-mediated Raf-1 recruitment to the plasma membrane to maintain signaling fidelity.

Authors:  Yvonne Light; Hugh Paterson; Richard Marais
Journal:  Mol Cell Biol       Date:  2002-07       Impact factor: 4.272

7.  Identification of cofilin and LIM-domain-containing protein kinase 1 as novel interaction partners of 14-3-3 zeta.

Authors:  Jörg Birkenfeld; Heinrich Betz; Dagmar Roth
Journal:  Biochem J       Date:  2003-01-01       Impact factor: 3.857

8.  14-3-3 proteins in neurological disorders.

Authors:  Molly Foote; Yi Zhou
Journal:  Int J Biochem Mol Biol       Date:  2012-05-18

9.  Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.

Authors:  H G Wang; S Takayama; U R Rapp; J C Reed
Journal:  Proc Natl Acad Sci U S A       Date:  1996-07-09       Impact factor: 11.205

10.  14-3-3 proteins associate with cdc25 phosphatases.

Authors:  D S Conklin; K Galaktionov; D Beach
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-15       Impact factor: 11.205
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