Literature DB >> 7933141

Protein-protein interactions between human cytomegalovirus IE2-580aa and pUL84 in lytically infected cells.

D J Spector1, M J Tevethia.   

Abstract

The human cytomegalovirus immediate-early protein IE2-580aa (ppUL122a) activates transcription of viral and cellular genes and represses its own transcription through sequence-specific binding to the major immediate-early promoter. In lytically infected cells, IE2-580aa interacts with a 75-kDa viral protein (p75), an early protein that is also synthesized at late times after infection. Here we show that p75 is the product of the UL84 gene. Its association with IE2-580aa in infected cells suggests that pUL84 is involved in transcription control.

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Year:  1994        PMID： 7933141      PMCID： PMC237200     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  41 in total

1.  Participation of two human cytomegalovirus immediate early gene regions in transcriptional activation of adenovirus promoters.

Authors:  M J Tevethia; D J Spector; K M Leisure; M F Stinski
Journal:  Virology       Date:  1987-12       Impact factor: 3.616

2.  Characterization of phosphoproteins and protein kinase activity of virions, noninfectious enveloped particles, and dense bodies of human cytomegalovirus.

Authors:  C Roby; W Gibson
Journal:  J Virol       Date:  1986-09       Impact factor: 5.103

3.  Temporal regulation of human cytomegalovirus transcription at immediate early and early times after infection.

Authors:  M W Wathen; D R Thomsen; M F Stinski
Journal:  J Virol       Date:  1981-05       Impact factor: 5.103

4.  Transcription in human fibroblasts permissively infected by human cytomegalovirus strain AD169.

Authors:  S H McDonough; D H Spector
Journal:  Virology       Date:  1983-02       Impact factor: 3.616

5.  Human cytomegalovirus DNA: restriction enzyme cleavage maps and map locations for immediate-early, early, and late RNAs.

Authors:  J M Demarchi
Journal:  Virology       Date:  1981-10-15       Impact factor: 3.616

6.  Structural analysis of the major immediate early gene of human cytomegalovirus.

Authors:  R M Stenberg; D R Thomsen; M F Stinski
Journal:  J Virol       Date:  1984-01       Impact factor: 5.103

7.  Identification and characterization of the human cytomegalovirus immediate-early region 2 gene that stimulates gene expression from an inducible promoter.

Authors:  T W Hermiston; C L Malone; P R Witte; M F Stinski
Journal:  J Virol       Date:  1987-10       Impact factor: 5.103

8.  Cloning and physical mapping of a gene fragment coding for a 64-kilodalton major late antigen of human cytomegalovirus.

Authors:  H Pande; S W Baak; A D Riggs; B R Clark; J E Shively; J A Zaia
Journal:  Proc Natl Acad Sci U S A       Date:  1984-08       Impact factor: 11.205

9.  Protein counterparts of human and simian cytomegaloviruses.

Authors:  W Gibson
Journal:  Virology       Date:  1983-07-30       Impact factor: 3.616

10.  Physical mapping of human cytomegalovirus genes: identification of DNA sequences coding for a virion phosphoprotein of 71 kDa and a viral 65-kDa polypeptide.

Authors:  B Nowak; A Gmeiner; P Sarnow; A J Levine; B Fleckenstein
Journal:  Virology       Date:  1984-04-15       Impact factor: 3.616
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  43 in total

1.  Viable human cytomegalovirus recombinant virus with an internal deletion of the IE2 86 gene affects late stages of viral replication.

Authors:  Veronica Sanchez; Charles L Clark; Judy Y Yen; Roopashree Dwarakanath; Deborah H Spector
Journal:  J Virol       Date:  2002-03       Impact factor: 5.103

2.  A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway.

Authors:  Peter Lischka; Gabriele Sorg; Michael Kann; Michael Winkler; Thomas Stamminger
Journal:  J Virol       Date:  2003-03       Impact factor: 5.103

3.  Activation of transcription of the human cytomegalovirus early UL4 promoter by the Ets transcription factor binding element.

Authors:  J Chen; M F Stinski
Journal:  J Virol       Date:  2000-11       Impact factor: 5.103

4.  Role of the specific interaction of UL112-113 p84 with UL44 DNA polymerase processivity factor in promoting DNA replication of human cytomegalovirus.

Authors:  Young-Eui Kim; Jin-Hyun Ahn
Journal:  J Virol       Date:  2010-06-10       Impact factor: 5.103

5.  New genes from old: redeployment of dUTPase by herpesviruses.

Authors:  Andrew J Davison; Nigel D Stow
Journal:  J Virol       Date:  2005-10       Impact factor: 5.103

6.  The IE2 60-kilodalton and 40-kilodalton proteins are dispensable for human cytomegalovirus replication but are required for efficient delayed early and late gene expression and production of infectious virus.

Authors:  Elizabeth A White; Christia J Del Rosario; Rebecca L Sanders; Deborah H Spector
Journal:  J Virol       Date:  2007-01-03       Impact factor: 5.103

7.  Interaction of HCMV UL84 with C/EBPalpha transcription factor binding sites within oriLyt is essential for lytic DNA replication.

Authors:  Dominique Kagele; Yang Gao; Kate Smallenburg; Gregory S Pari
Journal:  Virology       Date:  2009-07-23       Impact factor: 3.616

8.  Human cytomegalovirus UL84 localizes to the cell nucleus via a nuclear localization signal and is a component of viral replication compartments.

Authors:  Yiyang Xu; Kelly S Colletti; Gregory S Pari
Journal:  J Virol       Date:  2002-09       Impact factor: 5.103

9.  Characterization of the transcriptional repressive element of the human cytomegalovirus immediate-early US3 gene.

Authors:  B J Biegalke
Journal:  J Virol       Date:  1998-07       Impact factor: 5.103

10.  The human cytomegalovirus UL94 open reading frame encodes a conserved herpesvirus capsid/tegument-associated virion protein that is expressed with true late kinetics.

Authors:  B A Wing; G C Lee; E S Huang
Journal:  J Virol       Date:  1996-06       Impact factor: 5.103
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