Literature DB >> 7933139

Apoptosis induced in mouse hepatitis virus-infected cells by a virus-specific CD8+ cytotoxic T-lymphocyte clone.

S Shibata1, S Kyuwa, S K Lee, Y Toyoda, N Goto.   

Abstract

Morphological changes of mouse hepatitis virus-infected J774.1 cells cocultured with cloned mouse hepatitis virus-specific CD8+ cytotoxic T lymphocytes were examined by electron microscopy. Condensation and margination of chromatin, cellular shrinkage with severe vacuolar degeneration, and blebbing were observed. In addition, fragmentation of cellular DNA was observed, and a decrease in virus titer was accompanied by those changes. These findings show that the cloned cytotoxic T lymphocytes induce in the target cell an internal degradation program termed apoptosis, which results in virus clearance.

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Year:  1994        PMID： 7933139      PMCID： PMC237198     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  23 in total

1.  Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures.

Authors:  C A Smith; G T Williams; R Kingston; E J Jenkinson; J J Owen
Journal:  Nature       Date:  1989-01-12       Impact factor: 49.962

2.  DNA fragmentation and cytotoxicity caused by tumor necrosis factor is enhanced by interferon-gamma.

Authors:  G B Dealtry; M S Naylor; W Fiers; F R Balkwill
Journal:  Eur J Immunol       Date:  1987-05       Impact factor: 5.532

3.  Morphologic analysis of the interactions between lymphocytic choriomeningitis virus-specific cloned cytotoxic T cells and virus infected targets.

Authors:  S Patterson; J A Byrne; P W Lampert; M B Oldstone
Journal:  Lab Invest       Date:  1987-07       Impact factor: 5.662

Review 4.  How do cytotoxic T lymphocytes work in vivo?

Authors:  A Mullbacher; G L Ada
Journal:  Microb Pathog       Date:  1987-11       Impact factor: 3.738

5.  Mechanisms of immune lysis. II. CTL-induced nuclear disintegration of the target begins within minutes of cell contact.

Authors:  J H Russell; C B Dobos
Journal:  J Immunol       Date:  1980-09       Impact factor: 5.422

6.  Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo.

Authors:  J A Byrne; M B Oldstone
Journal:  J Virol       Date:  1984-09       Impact factor: 5.103

7.  Establishment of cytotoxic T-cell clones specific for cells infected with mouse hepatitis virus.

Authors:  K Yamaguchi; S Kyuwa; K Nakanaga; M Hayami
Journal:  J Virol       Date:  1988-07       Impact factor: 5.103

8.  Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells.

Authors:  J W Heusel; R L Wesselschmidt; S Shresta; J H Russell; T J Ley
Journal:  Cell       Date:  1994-03-25       Impact factor: 41.582

9.  Coronavirus-induced CNS disease: a model for virus-induced demyelination.

Authors:  M J Buchmeier; R G Dalziel; M J Koolen
Journal:  J Neuroimmunol       Date:  1988-12       Impact factor: 3.478

10.  In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific.

Authors:  A E Lukacher; V L Braciale; T J Braciale
Journal:  J Exp Med       Date:  1984-09-01       Impact factor: 14.307
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  15 in total

1.  Apoptosis-related proteins, BCL-2, BAX, FAS, FAS-L and PCNA in liver biopsies of patients with chronic hepatitis B virus infection.

Authors:  J Ehrmann; D Galuszková; J Ehrmann; I Krc; V Jezdinská; B Vojtések; P G Murray; Z Koláo
Journal:  Pathol Oncol Res       Date:  2000       Impact factor: 3.201

2.  Mouse hepatitis virus is cleared from the central nervous systems of mice lacking perforin-mediated cytolysis.

Authors:  M T Lin; S A Stohlman; D R Hinton
Journal:  J Virol       Date:  1997-01       Impact factor: 5.103

3.  Apoptosis and T-cell depletion during feline infectious peritonitis.

Authors:  B L Haagmans; H F Egberink; M C Horzinek
Journal:  J Virol       Date:  1996-12       Impact factor: 5.103

4.  Induction of apoptosis in murine coronavirus-infected cultured cells and demonstration of E protein as an apoptosis inducer.

Authors:  S An; C J Chen; X Yu; J L Leibowitz; S Makino
Journal:  J Virol       Date:  1999-09       Impact factor: 5.103

5.  The role of CD8+ T lymphocytes in coxsackievirus B3-induced myocarditis.

Authors:  A Henke; S Huber; A Stelzner; J L Whitton
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

6.  Improvements in brain and behavior following eradication of hepatitis C.

Authors:  Taylor Kuhn; Philip Sayegh; Jacob D Jones; Jason Smith; Manoj K Sarma; A Ragin; Elyse J Singer; M Albert Thomas; April D Thames; Steven A Castellon; Charles H Hinkin
Journal:  J Neurovirol       Date:  2017-05-30       Impact factor: 2.643

7.  Effects of JC virus infection on anti-apoptotic protein survivin in progressive multifocal leukoencephalopathy.

Authors:  Sergio Piña-Oviedo; Katarzyna Urbanska; Sujatha Radhakrishnan; Thersa Sweet; Krzysztof Reiss; Kamel Khalili; Luis Del Valle
Journal:  Am J Pathol       Date:  2007-04       Impact factor: 4.307

8.  Murine coronavirus-induced subacute fatal peritonitis in C57BL/6 mice deficient in gamma interferon.

Authors:  S Kyuwa; Y Tagawa; S Shibata; K Doi; K Machii; Y Iwakura
Journal:  J Virol       Date:  1998-11       Impact factor: 5.103

9.  Thymus involution induced by mouse hepatitis virus A59 in BALB/c mice.

Authors:  C Godfraind; K V Holmes; J P Coutelier
Journal:  J Virol       Date:  1995-10       Impact factor: 5.103

10.  Inhibition of interferon-gamma signaling in oligodendroglia delays coronavirus clearance without altering demyelination.

Authors:  John M González; Cornelia C Bergmann; Chandran Ramakrishna; David R Hinton; Roscoe Atkinson; Jason Hoskin; Wendy B Macklin; Stephen A Stohlman
Journal:  Am J Pathol       Date:  2006-03       Impact factor: 4.307
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