| Literature DB >> 7933058 |
E P Steffey1, J D Baggot, J H Eisele, N Willits, M J Woliner, K A Jarvis, A R Elliott, M Tagawa.
Abstract
In monkeys, dogs and swine (six each) we tested the reduction of the isoflurane MAC (minimal alveolar concentration) produced by 2 mg.kg-1 morphine intravenously (i.v.) and the concurrent effect on PCO2 with spontaneous ventilation. MAC fell to a minimum of 55% of control at 53 min in monkeys, 50% at 38 min in dogs and 13% at 33 min in swine. PaCO2 rose at constant MAC with morphine to 55-60 mmHg, but did not fall over the next several hours despite the decline of plasma morphine concentration, and the resulting needed rise in isoflurane concentration to keep the anaesthesia depth at 1 MAC. After isoflurane concentration had returned to pre-morphine control levels, naloxone immediately reduced PaCO2 to or below control level. Morphine pharmacokinetics in the three species studied conformed to a two-compartment model.Entities:
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Year: 1994 PMID： 7933058 DOI： 10.1111/j.1365-2885.1994.tb00234.x
Source DB: PubMed Journal: J Vet Pharmacol Ther ISSN： 0140-7783 Impact factor: 1.786