Literature DB >> 7932918

Characterization of 4-aminopyridine in overdose.

C M Stork1, R S Hoffman.   

Abstract

We report three cases of 4-aminopyridine overdose resulting in seizure activity. All patients were on therapeutic regimens for the treatment of multiple sclerosis. All patients were responsive to intensive supportive care, although the length of toxicity was prolonged more than 24 hours in one patient. Seizure activity was responsive to benzodiazepine and phenytoin therapy.

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Year:  1994        PMID： 7932918     DOI： 10.3109/15563659409011063

Source DB:  PubMed          Journal:  J Toxicol Clin Toxicol        ISSN： 0731-3810


  9 in total

1.  Potassium channel blocker, 4-aminopyridine-3-methanol, restores axonal conduction in spinal cord of an animal model of multiple sclerosis.

Authors:  Gary Leung; Wenjing Sun; Sarah Brookes; Daniel Smith; Riyi Shi
Journal:  Exp Neurol       Date:  2010-11-17       Impact factor: 5.330

2.  Comparative hemodynamic effects of levosimendan alone and in conjunction with 4-aminopyridine or calcium chloride in a rodent model of severe verapamil poisoning.

Authors:  Andis Graudins; Kathy Ka Ling Wong
Journal:  J Med Toxicol       Date:  2010-06

Review 3.  Potassium channel blockers as an effective treatment to restore impulse conduction in injured axons.

Authors:  Riyi Shi; Wenjing Sun
Journal:  Neurosci Bull       Date:  2011-02       Impact factor: 5.203

Review 4.  4-aminopyridine toxicity: a case report and review of the literature.

Authors:  Andrew M King; Nathan B Menke; Kenneth D Katz; Anthony F Pizon
Journal:  J Med Toxicol       Date:  2012-09

5.  Characteristics of the formation of chronic fatigue syndrome and approaches to its treatment in young patients with focal brain damage.

Authors:  A N Boiko; T T Batysheva; O V Matvievskaya; T M Manevich; E I Gusev
Journal:  Neurosci Behav Physiol       Date:  2007-03

6.  Impact of extended-release dalfampridine on walking ability in patients with multiple sclerosis.

Authors:  Keith C Hayes
Journal:  Neuropsychiatr Dis Treat       Date:  2011-04-28       Impact factor: 2.570

7.  A Massive Overdose of Dalfampridine.

Authors:  Laura J Fil; Payal Sud; Steven Sattler
Journal:  West J Emerg Med       Date:  2015-12-03

8.  Dalfampridine: review of its efficacy in improving gait in patients with multiple sclerosis.

Authors:  M A Sahraian; A H Maghzi; M Etemadifar; A Minagar
Journal:  J Cent Nerv Syst Dis       Date:  2011-05-16

9.  Prolonged Toxic Encephalopathy following Accidental 4-Aminopyridine Overdose.

Authors:  Maria Ballesta Méndez; Vincent van Pesch; Arnaud Capron; Philippe Hantson
Journal:  Case Rep Neurol Med       Date:  2014-04-17
  9 in total

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