Literature DB >> 7932727

Crystallization and preliminary X-ray analysis of the Fab fragment of a human monoclonal IgM rheumatoid factor (2A2).

M K Sohi1, B J Sutton, A L Corper, T Wan, R N Maini, C Brown, T Rijnders, D Beale, A Feinstein, A S Humphreys.   

Abstract

Crystals of the Fab fragment of a human monoclonal IgM rheumatoid factor have been obtained and are suitable for X-ray structure determination. This molecule, derived from the synovial B cells of a patient with rheumatoid arthritis, is an autoantibody with specificity for IgG Fc. The crystals have space group P2(1), cell dimensions a = 69.0 A, b = 76.6 A, c = 98.8 A and beta = 90.6 degrees, and diffract to a resolution of at least 2.8 A.

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Year:  1994        PMID： 7932727     DOI： 10.1006/jmbi.1994.1620

Source DB:  PubMed          Journal:  J Mol Biol        ISSN： 0022-2836            Impact factor:   5.469


  2 in total

1.  Crystal structure of a Staphylococcus aureus protein A domain complexed with the Fab fragment of a human IgM antibody: structural basis for recognition of B-cell receptors and superantigen activity.

Authors:  M Graille; E A Stura; A L Corper; B J Sutton; M J Taussig; J B Charbonnier; G J Silverman
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-09       Impact factor: 11.205

2.  Crystallization of a complex between the Fab fragment of a human immunoglobulin M (IgM) rheumatoid factor (RF-AN) and the Fc fragment of human IgG4.

Authors:  M K Sohi; A L Corper; T Wan; M Steinitz; R Jefferis; D Beale; M He; A Feinstein; B J Sutton; M J Taussig
Journal:  Immunology       Date:  1996-08       Impact factor: 7.397
  2 in total

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