| Literature DB >> 7932547 |
T C Barden1, B L Buckwalter, R T Testa, P J Petersen, V J Lee.
Abstract
A series of 9-(acylamino)doxycycline derivatives has been prepared. These analogs exhibit good activity against both tetracycline sensitive and tetracycline resistant Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria that are encoded with the efflux and ribosomal resistance gene factors. N,N-Dialkylglycylamido derivatives possessed the highest activity. Replacement of glycine moiety with other amino acids did not further enhance the activity.Entities:
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Year: 1994 PMID： 7932547 DOI： 10.1021/jm00046a003
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446