Literature DB >> 7932528

Synthesis of new acyclic pyrimidine nucleoside analogs as potential antiviral drugs.

K Eger1, E M Klünder, M Schmidt.   

Abstract

The synthesis of 6-[N-(4-hydroxybutyl)amino]pyrimidinone derivatives 18-23 and the acyclic phosphonate nucleoside analogs 29-30 is reported. Their cytotoxic and antiviral effects were investigated. 2,5-Diamino-6-[N-[2-(phosphonomethoxy)ethyl]amino]pyrimidin-4(3H)- one (30) showed strong antiviral effects, and 21 showed significant cytotoxic activity.

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Year:  1994        PMID： 7932528     DOI： 10.1021/jm00045a010

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  3 in total

1.  Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates.

Authors:  J Balzarini; C Pannecouque; E De Clercq; S Aquaro; C-F Perno; H Egberink; A Holý
Journal:  Antimicrob Agents Chemother       Date:  2002-07       Impact factor: 5.191

2.  Design, synthesis, antiviral and cytotoxic evaluation of novel acyclic phosphonate nucleotide analogues with a 5,6-dihydro-1H-[1,2,3]triazolo[4,5-d]pyridazine-4,7-dione system.

Authors:  Emilia Bankowska; Jan Balzarini; Iwona E Głowacka; Andrzej E Wróblewski
Journal:  Monatsh Chem       Date:  2014-01-25       Impact factor: 1.451

3.  Synthesis and antiviral activity evaluation of acyclic 2'-azanucleosides bearing a phosphonomethoxy function in the side chain.

Authors:  Mariola Koszytkowska-Stawińska; Erik De Clercq; Jan Balzarini
Journal:  Bioorg Med Chem       Date:  2009-05-03       Impact factor: 3.641
  3 in total

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