OBJECTIVE: To determine whether levels of either circulating immune complexes (IC) or complement activation fragments change as disease activity changes in children with polyarticular juvenile rheumatoid arthritis (JRA). METHODS: Twenty-six children with polyarticular JRA were examined over a time course of 4-21 months. Plasma complement activation fragments and IC were measured by commercially available enzyme linked immunoabsorbant assays. RESULTS: Both complement activation fragments and IC levels were lower in individual children when their articular disease was inactive. Children with persistently active disease had no change in any of these measures. CONCLUSION: Elevated levels of plasma IC and complement activation fragments are features of active polyarticular JRA. We believe our data support a role for the complement system in the pathophysiology of polyarticular JRA.
OBJECTIVE: To determine whether levels of either circulating immune complexes (IC) or complement activation fragments change as disease activity changes in children with polyarticular juvenile rheumatoid arthritis (JRA). METHODS: Twenty-six children with polyarticular JRA were examined over a time course of 4-21 months. Plasma complement activation fragments and IC were measured by commercially available enzyme linked immunoabsorbant assays. RESULTS: Both complement activation fragments and IC levels were lower in individual children when their articular disease was inactive. Children with persistently active disease had no change in any of these measures. CONCLUSION: Elevated levels of plasma IC and complement activation fragments are features of active polyarticular JRA. We believe our data support a role for the complement system in the pathophysiology of polyarticular JRA.
Authors: Nirit Mor-Vaknin; Ferdinand Kappes; Amalie E Dick; Maureen Legendre; Catalina Damoc; Seagal Teitz-Tennenbaum; Roland Kwok; Elisa Ferrando-May; Barbara S Adams; David M Markovitz Journal: Arthritis Rheum Date: 2011-02
Authors: Altan Ercan; Michael G Barnes; Melissa Hazen; Heather Tory; Lauren Henderson; Fatma Dedeoglu; Robert C Fuhlbrigge; Alexei Grom; Ingrid A Holm; Mark Kellogg; Susan Kim; Barbara Adamczyk; Pauline M Rudd; Mary Beth Son; Robert P Sundel; Dirk Foell; David N Glass; Susan D Thompson; Peter A Nigrovic Journal: Arthritis Rheum Date: 2012-09
Authors: James N Jarvis; Howard R Petty; Yuhong Tang; Mark Barton Frank; Philippe A Tessier; Igor Dozmorov; Kaiyu Jiang; Andrei Kindzelski; Yanmin Chen; Craig Cadwell; Mary Turner; Peter Szodoray; Julie L McGhee; Michael Centola Journal: Arthritis Res Ther Date: 2006 Impact factor: 5.156
Authors: James N Jarvis; Igor Dozmorov; Kaiyu Jiang; Mark Barton Frank; Peter Szodoray; Philip Alex; Michael Centola Journal: Arthritis Res Ther Date: 2003-11-06 Impact factor: 5.156