OBJECTIVE: This study was designed to see if humorally mediated negative inotropism contributes to the cardiac output (CO) depression seen during positive end-expiratory pressure (PEEP) ventilation. DESIGN: 8 pairs of piglets were used and a combined blood circulation was established between the two animals in each pair. One animal was ventilated with a PEEP of 15 cmH20 (donor) and the other was ventilated without PEEP (recipient). MEASUREMENT AND RESULTS: CO and stroke volume deteriorated in the donors by 32% and 44%, respectively, while no change was seen in the recipients. CONCLUSION: As humorally mediated negative inotropism during PEEP ventilation has earlier been demonstrated in dogs, the results suggest that this mechanism might be species-dependent.
OBJECTIVE: This study was designed to see if humorally mediated negative inotropism contributes to the cardiac output (CO) depression seen during positive end-expiratory pressure (PEEP) ventilation. DESIGN: 8 pairs of piglets were used and a combined blood circulation was established between the two animals in each pair. One animal was ventilated with a PEEP of 15 cmH20 (donor) and the other was ventilated without PEEP (recipient). MEASUREMENT AND RESULTS: CO and stroke volume deteriorated in the donors by 32% and 44%, respectively, while no change was seen in the recipients. CONCLUSION: As humorally mediated negative inotropism during PEEP ventilation has earlier been demonstrated in dogs, the results suggest that this mechanism might be species-dependent.
Authors: B Chernow; S Soldano; D Cook; P Lyons; M Barton; L C Casey; J R Fletcher; C R Lake Journal: Anaesth Intensive Care Date: 1986-11 Impact factor: 1.669
Authors: H L Edmonds; R W Spohr; R F Finnegan; G E Webb; J P Gott; L R Van Arsdall; L M Flint Journal: Crit Care Med Date: 1981-07 Impact factor: 7.598
Authors: J A Johnson; K D Kurz; S Siripaisarnpipat; D G Koivunen; D W Zeigler; T Sakamaki; C G Payne Journal: Hypertension Date: 1983 Jul-Aug Impact factor: 10.190