Literature DB >> 7929410

The peroxisome proliferator activated receptor regulates malic enzyme gene expression.

H Castelein1, T Gulick, P E Declercq, G P Mannaerts, D D Moore, M I Baes.   

Abstract

A new regulatory element for peroxisome proliferator activated receptor (PPAR)/retinoid X receptor (RXR) heterodimers was found in the promoter of the malic enzyme gene. Similar to previously characterized peroxisome proliferator response elements (PPREs), it consists of a direct repeat of sequences related to the half-site consensus AGGTCA with an interspacing of 1 base pair. Specific binding of PPAR/RXR heterodimers to this element was demonstrated. Furthermore, this sequence conferred ciprofibrate responsiveness of a reporter through the homologous malic enzyme or heterologous thymidine kinase promoters. This PPRE presumably mediates the transcriptional effects of peroxisome proliferators on malic enzyme expression. The presence of a PPRE in the promoter of this lipogenic enzyme suggests a broader function for the PPAR in the regulation of lipid metabolism.

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Year:  1994        PMID： 7929410

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  30 in total

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2.  Peroxisome proliferator-activated receptor subtype- and cell-type-specific activation of genomic target genes upon adenoviral transgene delivery.

Authors:  Ronni Nielsen; Lars Grøntved; Hendrik G Stunnenberg; Susanne Mandrup
Journal:  Mol Cell Biol       Date:  2006-08       Impact factor: 4.272

3.  Evolutionarily conserved gene family important for fat storage.

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Journal:  Proc Natl Acad Sci U S A       Date:  2007-12-26       Impact factor: 11.205

4.  Multiple parameters determine the specificity of transcriptional response by nuclear receptors HNF-4, ARP-1, PPAR, RAR and RXR through common response elements.

Authors:  H Nakshatri; P Bhat-Nakshatri
Journal:  Nucleic Acids Res       Date:  1998-05-15       Impact factor: 16.971

5.  Therapeutic Implications of PPARgamma in Human Osteosarcoma.

Authors:  Eric R Wagner; Bai-Cheng He; Liang Chen; Guo-Wei Zuo; Wenli Zhang; Qiong Shi; Qing Luo; Xiaoji Luo; Bo Liu; Jinyong Luo; Farbod Rastegar; Connie J He; Yawen Hu; Barrett Boody; Hue H Luu; Tong-Chuan He; Zhong-Liang Deng; Rex C Haydon
Journal:  PPAR Res       Date:  2010-02-16       Impact factor: 4.964

6.  Thyromimetic mode of action of peroxisome proliferators: activation of 'malic' enzyme gene transcription.

Authors:  R Hertz; V Nikodem; A Ben-Ishai; I Berman; J Bar-Tana
Journal:  Biochem J       Date:  1996-10-01       Impact factor: 3.857

7.  Peroxisome proliferator-activated receptor alpha target genes.

Authors:  Maryam Rakhshandehroo; Bianca Knoch; Michael Müller; Sander Kersten
Journal:  PPAR Res       Date:  2010-09-26       Impact factor: 4.964

8.  The Role of PPARα Activation in Liver and Muscle.

Authors:  Lena Burri; G Hege Thoresen; Rolf K Berge
Journal:  PPAR Res       Date:  2010-08-18       Impact factor: 4.964

9.  Identification of mRNAs differentially expressed in quiescence or in late G1 phase of the cell cycle in human breast cancer cells by using the differential display method.

Authors:  R S Alpan; S Sparvero; A B Pardee
Journal:  Mol Med       Date:  1996-07       Impact factor: 6.354

10.  Increased hepatic oxidative metabolism distinguishes the action of Peroxisome proliferator-activated receptor delta from Peroxisome proliferator-activated receptor gamma in the ob/ob mouse.

Authors:  Lee D Roberts; David G Hassall; Deborah A Winegar; John N Haselden; Andrew W Nicholls; Julian L Griffin
Journal:  Genome Med       Date:  2009-12-07       Impact factor: 11.117
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