Literature DB >> 7928621

The WD gene for Wilson's disease links to the hepatitis of LEC rats.

T Ono1, S Takada, M C Yoshida.   

Abstract

LEC rats develop an autosomal recessive hepatitis and subsequently liver cancer associated with copper accumulation in the liver similar to that of Wilson's disease. Using 71 backcross [(WKAH x LEC) x LEC] rats, linkage analysis of the hepatitis with the WD gene for Wilson's disease revealed identical segregation and no recombination event between these two genes. This result indicates that the WD gene is a prime candidate for the hts gene responsible for the hepatitis of LEC rats, and suggests that the hepatitis of LEC rats may be caused by a defect in a copper-transporting ATPase expressed in the liver.

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Year:  1994        PMID： 7928621      PMCID： PMC5919571          DOI： 10.1111/j.1349-7006.1994.tb02946.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  15 in total

1.  Sequential tests for the detection of linkage.

Authors:  N E MORTON
Journal:  Am J Hum Genet       Date:  1955-09       Impact factor: 11.025

2.  The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene.

Authors:  R E Tanzi; K Petrukhin; I Chernov; J L Pellequer; W Wasco; B Ross; D M Romano; E Parano; L Pavone; L M Brzustowicz
Journal:  Nat Genet       Date:  1993-12       Impact factor: 38.330

3.  Histochemical demonstration of copper in LEC rat liver.

Authors:  Y Fujii; K Shimizu; M Satoh; M Fujita; Y Fujioka; Y Li; Y Togashi; N Takeichi; K Nagashima
Journal:  Histochemistry       Date:  1993-10

4.  Eight closely linked loci place the Wilson disease locus within 13q14-q21.

Authors:  A M Bowcock; L A Farrer; J M Hebert; M Agger; I Sternlieb; I H Scheinberg; C H Buys; H Scheffer; M Frydman; T Chajek-Saul
Journal:  Am J Hum Genet       Date:  1988-11       Impact factor: 11.025

5.  Isolation and characterization of a human liver cDNA as a candidate gene for Wilson disease.

Authors:  Y Yamaguchi; M E Heiny; J D Gitlin
Journal:  Biochem Biophys Res Commun       Date:  1993-11-30       Impact factor: 3.575

6.  Assignment of the gene for Wilson disease to chromosome 13: linkage to the esterase D locus.

Authors:  M Frydman; B Bonné-Tamir; L A Farrer; P M Conneally; A Magazanik; S Ashbel; Z Goldwitch
Journal:  Proc Natl Acad Sci U S A       Date:  1985-03       Impact factor: 11.205

7.  New mutation causing hereditary hepatitis in the laboratory rat.

Authors:  M C Yoshida; R Masuda; M Sasaki; N Takeichi; H Kobayashi; K Dempo; M Mori
Journal:  J Hered       Date:  1987 Nov-Dec       Impact factor: 2.645

8.  Genetic linkage between copper accumulation and hepatitis/hepatoma development in LEC rats.

Authors:  H Sone; M Maeda; M Gotoh; K Wakabayashi; T Ono; M C Yoshida; N Takeichi; M Mori; S Hirohashi; T Sugimura
Journal:  Mol Carcinog       Date:  1992       Impact factor: 4.784

9.  Absence of linkage between the retinoblastoma gene and hts gene in the LEC rat: a model of human Wilson's disease.

Authors:  N Sasaki; Y Hayashizaki; N Kasai
Journal:  Jpn J Cancer Res       Date:  1993-10

10.  High susceptibility to hepatocellular carcinoma development in LEC rats with hereditary hepatitis.

Authors:  R Masuda; M C Yoshida; M Sasaki; K Dempo; M Mori
Journal:  Jpn J Cancer Res       Date:  1988-07
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  2 in total

1.  Expression of p21(waf-1/cip-1) is significantly induced in the livers of LEC rats with chronic liver injury.

Authors:  N Sawada; T Kojima; H Obata; H Isomura; S Atsumi; M Sawaki; N Tsuzuki; H Tobioka; Y Kokai; M Satoh; M Mori
Journal:  Jpn J Cancer Res       Date:  1996-11

2.  Role of p38 Mapk in development of acute hepatic injury in Long-Evans Cinnamon (LEC) rats, an animal model of human Wilson's disease.

Authors:  Shingo Kadowaki; Saori Meguro; Yoshitaka Imaizumi; Hiroshi Sakai; Daiji Endoh; Masanobu Hayashi
Journal:  J Vet Med Sci       Date:  2013-07-23       Impact factor: 1.267
  2 in total

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