Literature DB >> 7927755

The maltose regulon of Vibrio cholerae affects production and secretion of virulence factors.

H Lång1, G Jonson, J Holmgren, E T Palva.   

Abstract

The effects of maltose on production and secretion of virulence factors of Vibrio cholerae in strain X28214, classical biotype, and in maltose-defective transposon mutants constructed from this strain were characterized. Maltose was found to inhibit secretion of cholera toxin and to reduce production of the mannose-sensitive hemagglutinin and the soluble hemagglutinin-protease. In contrast, the amount of toxin-coregulated pilus was increased in the presence of maltose. The maltose effect was apparently mediated by genes of the maltose regulon, since inactivation of the malQ or malF gene of V. cholerae by transposon insertion was found to affect production and secretion of the same virulence factors that were responsive to maltose. The malQ and malF mutants showed, in addition, reduced virulence in an infant-mouse model. These results suggest that maltose may have a significant regulatory role in the production of virulence factors and that an intact maltose regulon is needed for full virulence of V. cholerae.

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Year:  1994        PMID： 7927755      PMCID： PMC303187          DOI： 10.1128/iai.62.11.4781-4788.1994

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  39 in total

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  20 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  1998-02-17       Impact factor: 11.205

5.  PafR, a novel transcription regulator, is important for pathogenesis in uropathogenic Escherichia coli.

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Journal:  Infect Immun       Date:  2014-07-28       Impact factor: 3.441

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7.  How 'arm-twisting' by the inducer triggers activation of the MalT transcription factor, a typical signal transduction ATPase with numerous domains (STAND).

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8.  Specific Imaging of Bacterial Infection Using 6″-18F-Fluoromaltotriose: A Second-Generation PET Tracer Targeting the Maltodextrin Transporter in Bacteria.

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Authors:  M Trucksis; J Michalski; Y K Deng; J B Kaper
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10.  malT knockout mutation invokes a stringent type gene-expression profile in Actinobacillus pleuropneumoniae in bronchoalveolar fluid.

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Journal:  BMC Microbiol       Date:  2009-09-14       Impact factor: 3.605
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