Literature DB >> 7926516

Expression of the mucosal homing receptor alpha 4 beta 7 in malignant lymphomatous polyposis of the intestine.

S T Pals1, P Drillenburg, B Dragosics, A I Lazarovits, T Radaszkiewicz.   

Abstract

Recent studies have identified the integrin alpha 4 beta 7 as a mucosal homing receptor that mediates lymphocyte migration to the intestinal mucosa by binding to MAd-CAM-1, which is a vascular recognition molecule (adressin) selectively expressed on mucosal endothelium. The expression of the alpha 4 beta 7 mucosal homing receptor was studied in eight cases of malignant lymphomatous polyposis (MLP). This unusual presentation of non-Hodgkin's lymphoma of mantle cell type is characterized by multifocal lymphomatous involvement of the gastrointestinal tract. Unlike nodal mantle cell lymphomas, cases of MLP showed expression of alpha 4 beta 7, suggesting that this homing receptor plays an important role in determining the characteristic mucosal dissemination pattern of MLP.

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Year:  1994        PMID： 7926516     DOI： 10.1016/0016-5085(94)90558-4

Source DB:  PubMed          Journal:  Gastroenterology        ISSN： 0016-5085            Impact factor:   22.682


  7 in total

1.  Homing receptor alpha4beta7 integrin expression predicts digestive tract involvement in mantle cell lymphoma.

Authors:  F Geissmann; A Ruskoné-Fourmestraux; O Hermine; P Bourquelot; C Belanger; J Audouin; A Delmer; E A Macintyre; B Varet; N Brousse
Journal:  Am J Pathol       Date:  1998-12       Impact factor: 4.307

2.  Preferential expression of the mucosal homing receptor integrin alpha 4 beta 7 in gastrointestinal non-Hodgkin's lymphomas.

Authors:  P Drillenburg; R van der Voort; G Koopman; B Dragosics; J H van Krieken; P Kluin; J Meenan; A I Lazarovits; T Radaszkiewicz; S T Pals
Journal:  Am J Pathol       Date:  1997-03       Impact factor: 4.307

3.  Expression of lymphocyte homing receptors and vascular addressins in low-grade gastric B-cell lymphomas of mucosa-associated lymphoid tissue.

Authors:  A Dogan; M Du; A Koulis; M J Briskin; P G Isaacson
Journal:  Am J Pathol       Date:  1997-11       Impact factor: 4.307

4.  Integrin β7-mediated regulation of multiple myeloma cell adhesion, migration, and invasion.

Authors:  Paola Neri; Li Ren; Abdel Kareem Azab; Matthew Brentnall; Kathy Gratton; Alexander C Klimowicz; Charles Lin; Peter Duggan; Pierfrancesco Tassone; Adnan Mansoor; Douglas A Stewart; Lawrence H Boise; Irene M Ghobrial; Nizar J Bahlis
Journal:  Blood       Date:  2011-04-07       Impact factor: 22.113

5.  Altered expression of alpha 4 beta 7, a gut homing integrin, by circulating and mucosal T cells in colonic mucosal inflammation.

Authors:  J Meenan; J Spaans; T A Grool; S T Pals; G N Tytgat; S J van Deventer
Journal:  Gut       Date:  1997-02       Impact factor: 23.059

6.  Primary follicular lymphoma of the small intestine: alpha4beta7 expression and immunoglobulin configuration suggest an origin from local antigen-experienced B cells.

Authors:  Richard J Bende; Laura A Smit; Janneke G Bossenbroek; Wilhelmina M Aarts; Marcel Spaargaren; Laurence de Leval; Guy E E Boeckxstaens; Steven T Pals; Carel J M van Noesel
Journal:  Am J Pathol       Date:  2003-01       Impact factor: 4.307

7.  Recombinant Viral Capsid Protein L2 (rVL2) of HPV 16 Suppresses Cell Proliferation and Glucose Metabolism via ITGB7/C/EBPβ Signaling Pathway in Cervical Cancer Cell Lines.

Authors:  Zhihong Chai; Yufei Yang; ZhongYi Gu; Xianli Cai; Wenwei Ye; Lin Kong; Xiaoxiao Qiu; Lingxiao Ying; Ziliang Wang; Linyou Wang
Journal:  Onco Targets Ther       Date:  2019-11-29       Impact factor: 4.147
  7 in total

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